The newly emerging Kappa, Delta, and Lambda SARS-CoV-2 variants are worrisome,
characterized with the double mutations E484Q/L452R, T478K/L452R, and F490S/L452Q …

The SARS-CoV-2 Delta (B. 1.617. 2) variant was identified in India in October 2020, and it
has quickly become the mainstream strain with strong toxicity and spread, posing great …

Multiple-site mutated SARS-CoV-2 Delta and Omicron variants may trigger immune escape
against existing monoclonal antibodies. Here, molecular dynamics simulations combined …

The Omicron lineage of SARS-CoV-2, which was first reported in November 2021, has
spread globally and become dominant, splitting into several sublineages. Experiments have …

One of the main obstacles in prevention and treatment of COVID-19 is the rapid evolution of
the SARS-CoV-2 Spike protein. Given that Spike is the main target of common treatments of …

This study investigated the allosteric action within the receptor-binding domain (RBD) of the
SARS-CoV-2 spike protein caused by class 3 monoclonal antibody (mAb) binding. As the …

Although the current coronavirus disease 2019 (COVID-19) vaccines have been used
worldwide to halt spread of the severe acute respiratory syndrome coronavirus 2 (SARS …

Continuing reports of new SARS-CoV-2 variants have caused worldwide concern and
created a challenging situation for clinicians. The recently reported variant B. 1.618, which …

The pandemic of the COVID-19 disease caused by SARS-CoV-2 has led to more than 200
million infections and over 4 million deaths worldwide. The progress in the developments of …

A structural understanding of the mechanism by which antibodies bind SARS-CoV-2 at the
atomic level is highly desirable as it can tell the development of more effective antibodies to …