Inadequate antibiotic therapy, generally defined as microbiologically ineffective anti-infective
therapy against the causative pathogen, can influence patient outcome. However, the …

In order to determine whether combination antibiotic therapy decreases mortality after
severe pneumococcal infection, a retrospective study of a cohort of 1,840 adult patients with …

Mortality related to serious infections in intensive care units (ICUs) is highest if empirical
therapy is not active against the organism causing the infection. However, excessive …

Background Modification of empirical antimicrobials when warranted by culture results or
clinical signs is recommended to control antimicrobial overuse and resistance. We aimed to …

Background Several strategies to optimise the use of antibiotics have been developed. Most
of these interventions can be classified as educational or restrictive. Restrictive measures …

Inadequate antimicrobial treatment, generally defined as microbiological documentation of
an infection that is not being effectively treated, is an important factor in the emergence of …

Objectives Early empiric antibiotic therapy in patients can improve clinical outcomes in Gram-
negative bacteraemia. However, the widespread prevalence of antibiotic-resistant …

Retrospective studies have suggested that combination antibiotic therapy for severe
bacteremic pneumococcal pneumonia may reduce mortality. We assessed this issue in a …

The rapid evolution of resistance, particularly among Gram-negative bacteria, requires
appropriate identification of patients at risk followed by administration of appropriate empiric …

To determine the impact of initial antimicrobial choice on 30-day mortality rate in patients
with community-acquired pneumonia due to Streptococcus pneumoniae (CAP-SP), a …