Redefining the IBDs using genome-scale molecular phenotyping

TS Furey, P Sethupathy, SZ Sheikh - Nature reviews Gastroenterology & …, 2019 - nature.com
Abstract The IBDs, Crohn's disease and ulcerative colitis, are chronic inflammatory
conditions of the gastrointestinal tract resulting from an aberrant immune response to enteric …

Multi-omics analysis of inflammatory bowel disease

H Huang, P Vangay, CE McKinlay, D Knights - Immunology letters, 2014 - Elsevier
Crohn's disease and ulcerative colitis, known together as inflammatory bowel disease (IBD),
are severe autoimmune disorders now causing gut inflammation and ulceration, among …

Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease

A Moustafa, W Li, EL Anderson… - Clinical and …, 2018 - journals.lww.com
OBJECTIVES: Inflammatory bowel diseases (IBD), comprised of Crohn's disease (CD) and
ulcerative colitis (UC), are characterized by a complex pathophysiology that is thought to …

Genetics and environmental interactions shape the intestinal microbiome to promote inflammatory bowel disease versus mucosal homeostasis

RB Sartor - Gastroenterology, 2010 - gastrojournal.org
Recent genome-wide genetic association studies and advances in molecular analysis of
microbial composition have improved dramatically our understanding of the pathogenesis of …

Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome

D Knights, KG Lassen, RJ Xavier - Gut, 2013 - gut.bmj.com
Studies of the genetics underlying inflammatory bowel diseases have increased our
understanding of the pathways involved in both ulcerative colitis and Crohn's disease and …

Inflammatory bowel disease: between genetics and microbiota

N Younis, R Zarif, R Mahfouz - Molecular biology reports, 2020 - Springer
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease that can
involve any part of the gastrointestinal tract. It includes two main disorders: Crohn's disease …

Determinants of IBD heritability: genes, bugs, and more

W Turpin, A Goethel, L Bedrani… - Inflammatory bowel …, 2018 - academic.oup.com
Defining the etiology of inflammatory bowel disease (IBD) continues to elude researchers, in
part due to the possibility that there may be different triggers for a spectrum of disease …

Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine

P Goyette, C Labbé, TT Trinh, RJ Xavier… - Annals of …, 2007 - Taylor & Francis
Crohn's disease (CD) and ulcerative colitis (UC), also known as inflammatory bowel
diseases (IBD), are characterized by chronic inflammation of the gastrointestinal tract. IBD is …

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

F Imhann, AV Vila, MJ Bonder, J Fu, D Gevers… - Gut, 2018 - gut.bmj.com
Objective Patients with IBD display substantial heterogeneity in clinical characteristics. We
hypothesise that individual differences in the complex interaction of the host genome and …

[HTML][HTML] Inflammatory bowel disease: genetics, epigenetics, and pathogenesis

I Loddo, C Romano - Frontiers in immunology, 2015 - frontiersin.org
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by
chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent …