siRNA Therapeutics for the Therapy of COVID-19 and Other Coronaviruses
The ongoing pandemic of global concern has killed about three million humans and affected
around 151 million people worldwide, as of April 30, 2021. Although recently approved …
around 151 million people worldwide, as of April 30, 2021. Although recently approved …
siRNA therapeutics against respiratory viral infections—What have we learned for potential COVID‐19 therapies?
Acute viral respiratory tract infections (AVRIs) are a major burden on human health and
global economy and amongst the top five causes of death worldwide resulting in an …
global economy and amongst the top five causes of death worldwide resulting in an …
Clinical pharmacology of siRNA therapeutics: current status and future prospects
ABSTRACT Introduction Small interfering RNA (siRNA) has emerged as a powerful tool for
post-transcriptional downregulation of multiple genes for various therapies. Naked siRNA …
post-transcriptional downregulation of multiple genes for various therapies. Naked siRNA …
[HTML][HTML] siRNA could be a potential therapy for COVID-19
S Ghosh, SM Firdous, A Nath - EXCLI journal, 2020 - ncbi.nlm.nih.gov
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA,
is a class of double-stranded non-coding RNA molecules, which is 20-25 base pairs in …
is a class of double-stranded non-coding RNA molecules, which is 20-25 base pairs in …
[HTML][HTML] Novel siRNA therapeutics demonstrate multi-variant efficacy against SARS-CoV-2
E Bowden-Reid, S Ledger, Y Zhang, F Di Giallonardo… - Antiviral Research, 2023 - Elsevier
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a respiratory
virus that causes COVID-19 disease, with an estimated global mortality of approximately 2 …
virus that causes COVID-19 disease, with an estimated global mortality of approximately 2 …
siRNA therapeutics: a clinical reality
PE Saw, EW Song - Science China Life Sciences, 2020 - Springer
Since the revolutionary discovery of RNA interference (RNAi), a remarkable progress has
been achieved in understanding and harnessing gene silencing mechanism; especially in …
been achieved in understanding and harnessing gene silencing mechanism; especially in …
The growth of siRNA-based therapeutics: Updated clinical studies
MM Zhang, R Bahal, TP Rasmussen… - Biochemical …, 2021 - Elsevier
More than two decades after the natural gene-silencing mechanism of RNA interference was
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection
VN Hariharan, M Shin, CW Chang… - Proceedings of the …, 2023 - National Acad Sciences
The continuous evolution of SARS-CoV-2 variants complicates efforts to combat the ongoing
pandemic, underscoring the need for a dynamic platform for the rapid development of pan …
pandemic, underscoring the need for a dynamic platform for the rapid development of pan …
[HTML][HTML] Developing effective siRNAs to reduce the expression of key viral genes of COVID-19
The COVID-19 pandemic has been raging worldwide for more than a year. Many efforts
have been made to create vaccines and develop new antiviral drugs to cope with the …
have been made to create vaccines and develop new antiviral drugs to cope with the …
Emergence of small interfering RNA-based gene drugs for various diseases
H Kurakula, S Vaishnavi, MY Sharif, S Ellipilli - ACS omega, 2023 - ACS Publications
Small molecule, peptide, and protein-based drugs have been developed over decades to
treat various diseases. The importance of gene therapy as an alternative to traditional drugs …
treat various diseases. The importance of gene therapy as an alternative to traditional drugs …