Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and
catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via …

Insulin-like growth factor 1 (IGF-1) is a key anabolic growth factor stimulating
phosphatidylinositol 3-kinase (PI3K)/Akt signaling which is well known for regulating muscle …

Background Insulin-like growth factor I (IGF-I) is an anabolic hormone that is known to
induce skeletal muscle hypertrophy. However, the signaling pathways mediating IGF-I's …

Activation of the PI3 kinase pathway can induce skeletal muscle hypertrophy, defined as an
increase in skeletal muscle mass. In mammals, skeletal muscle hypertrophy occurs as a …

Skeletal muscle development is a highly organized process controlled by evolutionarily
conserved networks of transcription factors, transferrable signaling molecules, and …

Skeletal muscle is an essential tissue that attaches to bones and facilitates body
movements. Insulin-like growth factor-1 (IGF-1) is a hormone found in blood that plays an …

M uscle aging is characterized by a decline in functional performance and restriction of
adaptability, due to progressive loss of muscle tissue coupled with a decrease in strength …

Skeletal muscle atrophy is a prominent and disabling feature of chronic wasting diseases.
Prevention or reversal of muscle atrophy by administration of skeletal muscle growth …

Skeletal muscle comprises approximately 40% of body weight, and is important for
locomotion, as well as for metabolic homeostasis. Adult skeletal muscle mass is maintained …

A common characteristic of aging is defective regeneration of skeletal muscle. The
molecular pathways underlying age‐related decline in muscle regenerative potential remain …