Organic anion transporting polypeptides (OATP) 1B1 and OATP1B3 are important hepatic
transporters that mediate the uptake of many clinically important drugs, including statins from …

Introduction: The in vivo fate and effectiveness of a drug depends highly on its absorption,
distribution, metabolism, excretion and toxicity (ADME-Tox). Organic anion transporting …

The organic anion transporting polypeptide (OATP) 2B1 is localized on the basolateral
membrane of hepatocytes and is expressed in enterocytes. Based on its distribution pattern …

Since the substrate specificities of OATP1B1, 1B3, and 2B1 are broad and overlapping, the
contribution of each isoform to the overall hepatic uptake is of concern when assessing …

The hepatic organic anion transporting polypeptides (OATPs) influence the
pharmacokinetics of several drug classes and are involved in many clinical drug–drug …

The importance of uptake transporters in determining drug disposition is increasingly
appreciated. While the focus of regulatory agencies worldwide has been on the hepatic …

The organic anion transporting polypeptide 2B1 (OATP2B1) was one of the first cloned
members of the SLCO family. However, its physiological and pharmacological role is still …

Members of the organic anion transporting polypeptide (OATP) family are responsible for the
cellular uptake of a broad range of endogenous compounds and xenobiotics in multiple …

The transporter-mediated uptake of drugs from blood into hepatocytes is a prerequisite for
intrahepatic drug action or intracellular drug metabolism before excretion. Therefore, uptake …

Purpose Membrane transport protein organic anion transporting polypeptide (OATP) 1B1
mediates hepatic uptake of many drugs (eg statins). The OATP1B1 c. 521 T> C (p. V174A) …