To define cellular mechanisms underlying kidney function and failure, the KPMP analyzes
biopsy tissue in a multicenter research network to build cell-level process maps of the …

Chronic kidney disease (CKD) has diverse phenotypic manifestations including structural
(such as fibrosis) and functional (such as glomerular filtration rate and albuminuria) …

Molecular characterization of the individual cell types in human kidney as well as model
organisms are critical in defining organ function and understanding translational aspects of …

Introduction Individuals with focal segmental glomerular sclerosis (FSGS) typically undergo
kidney biopsy only once, which limits the ability to characterize kidney cell gene expression …

The Nephrotic Syndrome Study Network (NEPTUNE) is a North American multicenter
collaborative consortium established to develop a translational research infrastructure for …

Single-cell sequencing studies have characterized the transcriptomic signature of cell types
within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional …

Background A challenge for single-cell genomic studies in kidney and other solid tissues is
generating a high-quality single-cell suspension that contains rare or difficult-to-dissociate …

Background The glomerulus is a specialized capillary bed that is involved in urine
production and BP control. Glomerular injury is a major cause of CKD, which is epidemic …

Background Acute kidney injury (AKI) occurs frequently in critically ill patients and is
associated with adverse outcomes. Cellular mechanisms underlying AKI and kidney cell …

Morphologic examination of tissue biopsies is essential for histopathological diagnosis.
However, accurate and scalable cellular quantification in human samples remains …