The biogenesis of mature, functional mRNA in eukaryotes often requires the precise
excision of noncoding, intervening sequences (ie, introns) which are present in the …

The excision of introns from nuclear mRNA precursors (pre-mRNA) is a fundamental step in
the biogenesis of most mRNAs in eukaryotic cells and occurs prior to the transport of newly …

A ubiquitous feature of eukaryotes is the presence of intervening sequences that interrupt
the coding regions of genes. Nuclear pre-mRNA splicing is the process by which these …

The primary transcripts of most nuclear protein-coding genes of eu-karyotes are interrupted
by intervening sequences (or introns) that are removed from the pre-mRNA in a process …

We determined the effect on splicing of 24 point mutations in the 5'and 3'splice region of the
large rabbit P-globin intron. In vitro, 3'AG mutations drastically reduce 5'cleavage and …

A characteristic feature of eukaryotic cells is that the primary transcription products of their
structural genes (pre-mRNAs) undergo a variety of post transcriptional modifications to …

Seven years have elapsed since the development of in vitro systems that efficiently splice
exogenously added pre-mRNA substrates (Hernandez & Keller 1983; Krainer et al 1984; Lin …

Virtually all pre-mRNA introns begin with the sequence/GU and end with
AG/(where/indicates a border between an exon and an Intron). We have previously shown …

One of the most surprising discoveries of molecular biology was the realization that
eukaryotic messenger RNAs (mRNA) are usually transcribed as precursors containing …

An important step of eukaryotic gene expression is pre‐mRNA splicing, the process of
removing intervening sequences (introns) from the nascent transcript (messenger RNA …