Differential metabolism of inorganic arsenic in mice from genetically diverse Collaborative Cross strains
Mice have been frequently used to study the adverse effects of inorganic arsenic (iAs)
exposure in laboratory settings. Like humans, mice metabolize iAs to monomethyl-As (MAs) …
exposure in laboratory settings. Like humans, mice metabolize iAs to monomethyl-As (MAs) …
Strain-dependent disposition of inorganic arsenic in the mouse
MF Hughes, EM Kenyon, BC Edwards, CT Mitchell… - Toxicology, 1999 - Elsevier
Recent studies have suggested that polymorphisms in the methylation of inorganic arsenic
(iAs) exist in animals and humans. Methylation of iAs is an important step in the elimination …
(iAs) exist in animals and humans. Methylation of iAs is an important step in the elimination …
Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in mice following acute oral administration of arsenate
EM Kenyon, LM Del Razo, MF Hughes - Toxicological Sciences, 2005 - academic.oup.com
The relationship of exposure dose and tissue concentration of parent chemical and
metabolites is a critical issue in cases where toxicity may be mediated by a metabolite or by …
metabolites is a critical issue in cases where toxicity may be mediated by a metabolite or by …
Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following subchronic exposure to arsenate in drinking …
EM Kenyon, MF Hughes, BM Adair, JH Highfill… - Toxicology and applied …, 2008 - Elsevier
The relationship of exposure and tissue concentration of parent chemical and metabolites
over prolonged exposure is a critical issue for chronic toxicities mediated by metabolite (s) …
over prolonged exposure is a critical issue for chronic toxicities mediated by metabolite (s) …
Fate of arsenicals in mice carrying the human AS3MT gene exposed to environmentally relevant levels of arsenite in drinking water
C Douillet, M Miller, PH Cable, Q Shi, H El-Masri… - Scientific Reports, 2023 - nature.com
Although mice are widely used to study adverse effects of inorganic arsenic (iAs), higher
rates of iAs methylation in mice than in humans may limit their utility as a model organism. A …
rates of iAs methylation in mice than in humans may limit their utility as a model organism. A …
Dose-dependent urinary phenotype of inorganic arsenic methylation in mice with a focus on trivalent methylated metabolites
EA García-Montalvo, OL Valenzuela… - Toxicology …, 2011 - Taylor & Francis
Inorganic arsenic (iAs) exposure has been associated with the increased risk of various
forms of cancer and of non-cancerous diseases. Metabolic conversions of iAs that yield …
forms of cancer and of non-cancerous diseases. Metabolic conversions of iAs that yield …
Comparison of speciated arsenic levels in the liver and brain of mice between arsenate and arsenite exposure at the early life
C Lu, F Zhao, D Sun, Y Zhong, X Yu, G Li… - Environmental …, 2014 - Wiley Online Library
The aim of this study was to compare the risk from exposure to arsenate (iAsV) or arsenite
(iAsIII) at the early life. Mother mice were exposed to equimolar dose of iAsV and iAsIII via …
(iAsIII) at the early life. Mother mice were exposed to equimolar dose of iAsV and iAsIII via …
Mouse arsenic (+ 3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water
Abstract Arsenic (+ 3 oxidation state) methyltransferase (As3mt) catalyzes methylation of
inorganic arsenic (iAs) producing a number of methylated arsenic metabolites. Although …
inorganic arsenic (iAs) producing a number of methylated arsenic metabolites. Although …
Comparison of tissue dosimetry in the mouse following chronic exposure to arsenic compounds
PR Gentry, TR Covington, G Lawrence… - Journal of Toxicology …, 2005 - Taylor & Francis
Several chronic bioassays have been conducted in multiple strains of mice in which various
concentrations of arsenate or arsenite were administered in the drinking water without a …
concentrations of arsenate or arsenite were administered in the drinking water without a …
Metabolism and disposition of arsenic species from controlled dosing with sodium arsenite in adult female CD-1 mice. III. Toxicokinetic studies following oral and …
NC Twaddle, M Vanlandingham, JW Fisher… - Food and Chemical …, 2018 - Elsevier
Arsenic is a ubiquitous contaminant, with typical dietary intake below 1 μg/kg bw/d and
drinking water exposures up to 50 μg/kg bw/d. Arsenic exposures are associated with …
drinking water exposures up to 50 μg/kg bw/d. Arsenic exposures are associated with …