Scientific evidence underlying contraindications to the ketogenic diet: An update

M Watanabe, D Tuccinardi, I Ernesti… - Obesity …, 2020 - Wiley Online Library
First identified as a feasible treatment for intractable epilepsy, the ketogenic diet (KD) has
recently gained popularity thanks to growing evidence on applications such as weight loss …

Management of multifactorial idiopathic epilepsy in EL mice with caloric restriction and the ketogenic diet: role of glucose and ketone bodies

JG Mantis, NA Centeno, MT Todorova, R McGowan… - Nutrition & …, 2004 - Springer
Background The high fat, low carbohydrate ketogenic diet (KD) was developed as an
alternative to fasting for seizure management. While the mechanisms by which fasting and …

Ketone administration for seizure disorders: history and rationale for ketone esters and metabolic alternatives

AM Poff, JM Rho, DP D'Agostino - Frontiers in Neuroscience, 2019 - frontiersin.org
The ketogenic diet (KD) is a high-fat, low-carbohydrate treatment for medically intractable
epilepsy. One of the hallmark features of the KD is the production of ketone bodies which …

Neuroprotective and disease-modifying effects of the ketogenic diet

M Gasior, MA Rogawski… - Behavioural pharmacology, 2006 - journals.lww.com
The ketogenic diet has been in clinical use for over 80 years, primarily for the symptomatic
treatment of epilepsy. A recent clinical study has raised the possibility that exposure to the …

Ketogenic diet: overview, types, and possible anti-seizure mechanisms

M Barzegar, M Afghan, V Tarmahi, M Behtari… - Nutritional …, 2021 - Taylor & Francis
The ketogenic diet (KD) has been used for a long time as a therapeutic approach for drug-
resistant epilepsy. It is a high-fat, low-carbohydrate, and adequate protein diet. There are …

The effects of the ketogenic diet on behavior and cognition

T Hallböök, S Ji, S Maudsley, B Martin - Epilepsy research, 2012 - Elsevier
Multiple forms of the ketogenic diet (KD) have been successfully used to treat drug-resistant
epilepsy, however its mainstream use as a first-line therapy is still limited. Further …

Do ketone bodies mediate the anti-seizure effects of the ketogenic diet?

TA Simeone, KA Simeone, CE Stafstrom, JM Rho - Neuropharmacology, 2018 - Elsevier
Although the mechanisms underlying the anti-seizure effects of the high-fat ketogenic diet
(KD) remain unclear, a long-standing question has been whether ketone bodies (ie, β …

Ketogenic diet and neuroinflammation

S Koh, N Dupuis, S Auvin - Epilepsy Research, 2020 - Elsevier
The high-fat, low-carbohydrate ketogenic diet (KD) is an established treatment for drug-
resistant epilepsy with a proven efficacy. The KD is being explored for Febrile Infection …

Ketogenic diet for epilepsy: an overview of systematic review and meta-analysis

Y Ruan, L Chen, D She, Y Chung, L Ge… - European Journal of …, 2022 - nature.com
Ketogenic diet therapy (KDT) is an established nonpharmacologic treatment in various types
of epilepsy. We aim to evaluate the quality of the systematic reviews and meta-analyses …

Long-term monitoring of the ketogenic diet: Do's and Don'ts

AGC Bergqvist - Epilepsy research, 2012 - Elsevier
The ketogenic diet (KD) is an effective treatment for epilepsy and like other treatments it is
not without side effects. The side effects encountered are related to the diet composition and …