Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of
triglycerides to high-density lipoprotein cholesterol (TG: HDL-C) is a surrogate marker of IR …

Recent genome-wide association studies have described many loci implicated in type 2
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the …

Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the
mechanisms underlying this link remain obscure. Using an integrative genomic approach …

To identify genetic variants influencing plasma lipid concentrations, we first used genotype
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 …

Genome-wide association studies have identified common variants that only partially
explain the genetic risk for type 2 diabetes (T2D). Using genome-wide association data from …

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL)
cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for …

Insulin resistance and the metabolic syndrome are complex metabolic traits and key risk
factors for the development of cardiovascular disease. They result from the interplay of …

Low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol,
triglycerides, and total cholesterol are heritable, modifiable, risk factors for coronary artery …

Genome-wide association studies (GWAS) have identified multiple loci associated with
plasma lipid concentrations,,,,. Common variants at these loci together explain< 10% of …

Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular
disease,. Using genome-wide association data from three studies (n= 8,816 that included …