Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

Decreased endothelial nitric oxide (NO) bioavailability as it relates to endothelial dysfunction
plays an important role in various cardiovascular disorders, including atherosclerosis …

Reduced production of nitric oxide (NO) is one of the first indications of endothelial
dysfunction and precedes overt cardiovascular disease. Increased expression of Arginase …

Arginase shares a common substrate, L‐arginine, with nitric oxide (NO) synthase (NOS). It is
thought that arginase, if it is expressed in the endothelium, might play a pivotal role in the …

Arginine metabolism plays a major role in cardiovascular physiology and pathophysiology,
largely via nitric oxide (NO)-dependent processes. It is becoming increasingly apparent …

ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR
FUNCTION - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Endothelial dysfunction and resulting vascular pathology have been identified as an early
hallmark of multiple diseases, including diabetes mellitus. One of the major contributors to …

The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

Background—Endothelial dysfunction plays an important role in the early development of
atherosclerosis and vascular complications in type 2 diabetes mellitus. Increased …