[HTML][HTML] Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders

N Singewald, C Schmuckermair, N Whittle… - Pharmacology & …, 2015 - Elsevier
Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …

Can fear extinction be enhanced? A review of pharmacological and behavioral findings

PJ Fitzgerald, JR Seemann, S Maren - Brain research bulletin, 2014 - Elsevier
There is considerable interest, from both a basic and clinical standpoint, in gaining a greater
understanding of how pharmaceutical or behavioral manipulations alter fear extinction in …

Combining pharmacotherapy with cognitive behavioral therapy: traditional and new approaches

M Davis, M Barad, M Otto… - Journal of Traumatic …, 2006 - Wiley Online Library
Given the ever‐increasing sources of trauma both nationally and globally, it is imperative to
develop new and better treatments for anxiety disorders such as posttraumatic stress …

The use of cognitive enhancers in animal models of fear extinction

GB Kaplan, KA Moore - Pharmacology Biochemistry and Behavior, 2011 - Elsevier
In anxiety disorders, such as posttraumatic stress disorders and phobias, classical
conditioning pairs natural (unconditioned) fear-eliciting stimuli with contextual or discrete …

From the neurobiology of extinction to improved clinical treatments

FG Morrison, KJ Ressler - Depression and anxiety, 2014 - Wiley Online Library
The neural circuitry underlying the fear response is extremely well conserved across
mammalian species, which has allowed for the rapid translation of research findings in …

Cognitive enhancers for anxiety disorders

SG Hofmann, JAJ Smits, A Asnaani, CA Gutner… - Pharmacology …, 2011 - Elsevier
Cognitive-behavioral therapy is an effective intervention for anxiety disorders. However, a
significant number of people do not respond or only show partial response even after an …

A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: potential extinction enhancers

RM De Bitencourt, FA Pamplona, RN Takahashi - Neuropharmacology, 2013 - Elsevier
Emotional learning is extremely important for the survival of an individual. However, once
acquired, emotional associations are not always expressed. The regulation of emotional …

An overview of translationally informed treatments for posttraumatic stress disorder: animal models of Pavlovian fear conditioning to human clinical trials

ME Bowers, KJ Ressler - Biological psychiatry, 2015 - Elsevier
Posttraumatic stress disorder manifests after exposure to a traumatic event and is
characterized by avoidance/numbing, intrusive symptoms and flashbacks, mood and …

Augmentation of extinction and inhibitory learning in anxiety and trauma-related disorders

LAM Lebois, AV Seligowski, JD Wolff… - Annual review of …, 2019 - annualreviews.org
Although the fear response is an adaptive response to threatening situations, a number of
psychiatric disorders feature prominent fear-related symptoms caused, in part, by failures of …

State-of-the-art and future directions for extinction as a translational model for fear and anxiety

MG Craske, D Hermans… - … Transactions of the …, 2018 - royalsocietypublishing.org
Through advances in both basic and clinical scientific research, Pavlovian fear conditioning
and extinction have become an exemplary translational model for understanding and …