Endocannabinoid system and synaptic plasticity: implications for emotional responses

MP Viveros, EM Marco, R Llorente… - Neural …, 2007 - Wiley Online Library
The endocannabinoid system has been involved in the regulation of anxiety, and proposed
as an inhibitory modulator of neuronal, behavioral and adrenocortical responses to stressful …

Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders

BB Gorzalka, MN Hill, CJ Hillard - Neuroscience & Biobehavioral Reviews, 2008 - Elsevier
The endocannabinoid system is a widely distributed, neuromodulatory system which serves
an integral role in regulating synaptic transmission. The presence of this system in stress …

[HTML][HTML] Neurobiological interactions between stress and the endocannabinoid system

M Morena, S Patel, JS Bains, MN Hill - Neuropsychopharmacology, 2016 - nature.com
Stress affects a constellation of physiological systems in the body and evokes a rapid shift in
many neurobehavioral processes. A growing body of work indicates that the …

Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin‐releasing hormone signaling

K Kamprath, W Plendl, G Marsicano… - Genes, Brain and …, 2009 - Wiley Online Library
Recent evidence showed that the endocannabinoid system plays an important role in the
behavioral adaptation of stress and fear responses. In this study, we chose a behavioral …

[HTML][HTML] Targeting the endocannabinoid system in the treatment of posttraumatic stress disorder: A promising case of preclinical-clinical translation?

LM Mayo, CA Rabinak, MN Hill, M Heilig - Biological psychiatry, 2022 - Elsevier
The endocannabinoid (eCB) system is one the most ubiquitous signaling systems of the
brain and offers a rich pharmacology including multiple druggable targets. Preclinical …

Cannabinoids and emotionality: a neuroanatomical perspective

RJ McLaughlin, G Gobbi - Neuroscience, 2012 - Elsevier
The endocannabinoid system has recently emerged as a promising therapeutic target for the
treatment of stress-related emotional disorders. A growing literature base has collectively …

Endocannabinoids, cannabinoids and the regulation of anxiety

GN Petrie, AS Nastase, RJ Aukema, MN Hill - Neuropharmacology, 2021 - Elsevier
Cannabis has been used for hundreds of years, with its ability to dampen feelings of anxiety
often reported as a primary reason for use. Only recently has the specific role cannabinoids …

Stress regulates endocannabinoid-CB1 receptor signaling

CJ Hillard - Seminars in immunology, 2014 - Elsevier
The CB1 cannabinoid receptor is a G protein coupled receptor that is widely expressed
throughout the brain. The endogenous ligands for the CB1 receptor (endocannabinoids) are …

The endocannabinoid system modulates stress, emotionality, and inflammation

MS Crowe, SR Nass, KM Gabella, SG Kinsey - Brain, behavior, and …, 2014 - Elsevier
The physiological and behavioral effects of stress are well characterized. Endocannabinoids
are produced on demand and function to attenuate many of the physiological effects of the …

The endocannabinoid system and the treatment of mood and anxiety disorders

MN Hill, BB Gorzalka - … (Formerly Current Drug Targets-CNS & …, 2009 - ingentaconnect.com
The central endocannabinoid system is a neuroactive lipid signalling system in the brain
which acts to control neurotransmitter release. The expression patterns of this system …