A long-held goal in sequencing has been to use a voltage-biased nanoscale pore in a membrane to measure the passage of a linear, single-stranded (ss) DNA or RNA molecule …
B Luan, G Stolovitzky, G Martyna - Nanoscale, 2012 - pubs.rsc.org
DNA sequencing methods based on nanopores could potentially represent a low-cost and high-throughput pathway to practical genomics, by replacing current sequencing methods …
Nanopore-based DNA analysis is a single-molecule technique with revolutionary potential. It promises to carry out a range of analyses, orders of magnitude faster than current methods …
D Fologea, M Gershow, B Ledden, DS McNabb… - Nano …, 2005 - ACS Publications
Voltage biased solid-state nanopores are used to detect and characterize individual single stranded DNA molecules of fixed micrometer length by operating a nanopore detector at pH …
A nanopore-based device provides single-molecule detection and analytical capabilities that are achieved by electrophoretically driving molecules in solution through a nano-scale …
M Wanunu - Physics of life reviews, 2012 - Elsevier
Much more than ever, nucleic acids are recognized as key building blocks in many of lifeʼs processes, and the science of studying these molecular wonders at the single-molecule …
Solid-state nanopores have emerged as possible candidates for next-generation DNA sequencing devices. In such a device, the DNA sequence would be determined by …
Nanopores could potentially be used to perform single-molecule DNA sequencing at low cost and with high throughput,,,. Although single base resolution and differentiation have …
Over 15 years ago, the ability to electrically detect and characterize individual polynucleotides as they are driven through a single protein ion channel was suggested as a …