Serological assays estimate highly variable SARS-CoV-2 neutralizing antibody activity in recovered COVID-19 patients

LL Luchsinger, BP Ransegnola, DK Jin… - Journal of clinical …, 2020 - Am Soc Microbiol
The development of neutralizing antibodies (NAbs) against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) following infection or vaccination is likely to be …

Longitudinal serological analysis and neutralizing antibody levels in coronavirus disease 2019 convalescent patients

F Muecksch, H Wise, B Batchelor… - The Journal of …, 2021 - academic.oup.com
Background Understanding the longitudinal trajectory of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) antibodies is crucial for diagnosis of prior infection and …

A highly specific and sensitive serological assay detects SARS-CoV-2 antibody levels in COVID-19 patients that correlate with neutralization

D Peterhoff, V Glück, M Vogel, P Schuster, A Schütz… - Infection, 2021 - Springer
Objective The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
challenges national health systems and the global economy. Monitoring of infection rates …

Neutralizing antibody responses in COVID-19 convalescent sera

WT Lee, RC Girardin, AP Dupuis… - The Journal of …, 2021 - academic.oup.com
Passive transfer of antibodies from COVID-19 convalescent patients is being used as an
experimental treatment for eligible patients with SARS-CoV-2 infections. The United States …

Disease severity, fever, age, and sex correlate with SARS-CoV-2 neutralizing antibody responses

S Schlickeiser, T Schwarz, S Steiner, K Wittke… - Frontiers in …, 2021 - frontiersin.org
Clinical trials on the use of COVID-19 convalescent plasma remain inconclusive. While data
on safety is increasingly available, evidence for efficacy is still sparse. Subgroup analyses …

SARS-CoV-2 serologic assay needs for the next phase of the US COVID-19 pandemic response

AV Gundlapalli, RM Salerno, JT Brooks… - Open forum …, 2021 - academic.oup.com
Background There is a need for validated and standardized severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) quantitative immunoglobulin G (IgG) and …

Clinical, laboratory, and temporal predictors of neutralizing antibodies against SARS-CoV-2 among COVID-19 convalescent plasma donor candidates

J Boonyaratanakornkit, C Morishima… - The Journal of …, 2021 - Am Soc Clin Investig
BACKGROUND SARS-CoV-2–specific antibodies may protect from reinfection and disease,
providing rationale for administration of plasma containing SARS-CoV-2–neutralizing …

Longitudinal dynamics of the neutralizing antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection

K Wang, QX Long, HJ Deng, J Hu… - Clinical Infectious …, 2021 - academic.oup.com
Abstract Background Coronavirus disease 2019 (COVID-19) is a global pandemic with no
licensed vaccine or specific antiviral agents for therapy. Little is known about the longitudinal …

Evaluation of high-throughput SARS-CoV-2 serological assays in a longitudinal cohort of patients with mild COVID-19: clinical sensitivity, specificity, and association …

A Bal, B Pozzetto, MA Trabaud, V Escuret… - Clinical …, 2021 - academic.oup.com
Background The association between SARS-CoV-2 commercial serological assays and
virus neutralization test (VNT) has been poorly explored in mild patients with COVID-19 …

A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation

AE Muruato, CR Fontes-Garfias, P Ren… - Nature …, 2020 - nature.com
Virus neutralization remains the gold standard for determining antibody efficacy. Therefore,
a high-throughput assay to measure SARS-CoV-2 neutralizing antibodies is urgently …