The fms-like tyrosine kinase 3 (FLT3) plays an important role in both normal and malignant
hematopoiesis. Activating mutations in the FLT3 receptor can be detected in approximately …

The receptor tyrosine kinase fms-like tyrosine kinase 3 (FLT3), involved in regulating
survival, proliferation, and differentiation of hematopoietic stem/progenitor cells, is …

Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene arise in 25-30% of all acute myeloid
leukemia (AML) patients. These mutations lead to constitutive activation of the protein …

Introduction: Activating mutations of the FMS-like tyrosine kinase 3 (FLT3) gene occur at
high frequency in acute myeloid leukemia (AML), being detected in> 30% of patients at …

The receptor tyrosine kinase FLT3 is an important regulatory molecule in hematopoiesis and
is expressed on the blasts in most cases of acute leukemia. Activating mutations of this …

Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene are often present in newly
diagnosed acute myeloid leukemia (AML) patients with an incidence rate of approximately …

Mutations in the fms-like tyrosine kinase 3 (FLT3) gene are detected in approximately one-
third of patients with newly diagnosed acute myeloid leukemia (AML). These consist of the …

Fms-like tyrosine kinase-3 (FLT3) mutations occur in approximately 30% of acute myeloid
leukemia (AML) cases, suggesting FLT3 as an attractive target for AML treatment. Early …

Abstract Since the Food and Drug Administration approval of imatinib for treatment of
chronic myeloid leukemia in 2001, tyrosine kinase inhibitors (TKIs) have become a mainstay …

FMS‐like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that appears to play a
significant role in leukaemogenesis. Activating mutations of FLT3 are present in …