Introduction Vascular factors increase the risk of Alzheimer's disease (AD). We investigated
the associations between such factors, longitudinal AD cerebrospinal fluid biomarkers, and …

Alzheimer's disease is characterized by the extracellular accumulation of the amyloid β in
the form of amyloid plaques and the intracellular deposition of the microtubule-associated …

Vascular dementia (VaD) is the second most common form of dementia in the United States
and is characterized as a cerebral vessel vascular disease that leads to ischemic episodes …

The microtubule-associated protein (MAP) tau plays a critical role in the pathogenesis of
Alzheimer's disease (AD) and several related disorders collectively known as tauopathies …

Abnormal accumulation of misfolded tau aggregates is a pathological hallmark of various
tauopathies including Alzheimer's disease (AD). Although tau is a cytosolic microtubule …

The molecular causes and the genetic and environmental modifying factors of the sporadic
form of Alzheimer's disease (AD) remain elusive. Extrapolating from the known mutations …

Most neurodegenerative disorders are associated with aggregated protein deposits. In the
case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular …

Vascular abnormalities are a key feature of Alzheimer's disease (AD). Imaging of cerebral
vascular reactivity (CVR) is a powerful tool to investigate vascular health in clinical …

With the aging of the population comes a heightened sense of urgency to do something
about Alzheimer's disease (AD), the most common dementia disorder. Treatment for AD is …

Background Intracellular accumulation of tau as neurofibrillary tangles (NFTs) is the
hallmark of Alzheimer's disease (AD) as well as in other tauopathies. Tau is present not only …