Silencing of SARS-CoV spike gene by small interfering RNA in HEK 293T cells

Z Qin, P Zhao, X Zhang, J Yu, M Cao, L Zhao… - Biochemical and …, 2004 - Elsevier
Two candidate small interfering RNAs (siRNAs) corresponding to severe acute respiratory
syndrome-associated coronavirus (SARS-CoV) spike gene were designed and in vitro …

[HTML][HTML] Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles

P Zhao, ZL Qin, JS Ke, Y Lu, M Liu, W Pan, LJ Zhao… - FEBS letters, 2005 - Elsevier
SARS-CoV is a newly identified coronavirus that causes severe acute respiratory syndrome
(SARS). Currently, there is no effective method available for prophylaxis and treatment of …

Potent and specific inhibition of SARS-CoV antigen expression by RNA interference

P Tao, J Zhang, N Tang, B Zhang, T He… - Chinese medical …, 2005 - mednexus.org
Background Severe acute respiratory syndrome (SARS) is an infectious disease caused by
SARS-CoV. There are no effective antiviral drugs for SARS although the epidemic of SARS …

Small interfering RNA effectively inhibits the expression of SARS coronavirus membrane gene at two novel targeting sites

Y Wang, YL Cao, F Yang, Y Zhang, SH Wang, L Liu - Molecules, 2010 - mdpi.com
Small interfering RNA (siRNA) is a class of duplex RNA molecules of 21-25 nt nucleotides in
length functioning post-transcriptionally to downregulate targeted gene expression. The …

[HTML][HTML] Silencing SARS-CoV Spike protein expression in cultured cells by RNA interference

Y Zhang, T Li, L Fu, C Yu, Y Li, X Xu, Y Wang, H Ning… - FEBS letters, 2004 - Elsevier
The severe acute respiratory syndrome (SARS) has been one of the most epidemic
diseases threatening human health all over the world. Based on clinical studies, SARS-CoV …

Inhibition of SARS-CoV replication cycle by small interference RNAs silencing specific SARS proteins, 7a/7b, 3a/3b and S

S Åkerström, A Mirazimi, YJ Tan - Antiviral research, 2007 - Elsevier
The severe acute respiratory syndrome coronavirus (SARS CoV) genome has 14 potential
open reading frames (ORFs). The first ORF is translated from the full-length genomic mRNA …

Influence of intron and exon splicing enhancers on mammalian cell expression of a truncated spike protein of SARS-CoV and its implication for subunit vaccine …

CY Chang, WWL Hong, P Chong, SC Wu - Vaccine, 2006 - Elsevier
The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is
important for vaccine development. A truncated S protein of the TW1 strain, STR2 (88kDa) …

Inhibition of replication and infection of severe acute respiratory syndrome-associated coronavirus with plasmid-mediated interference RNA

B Ni, X Shi, Y Li, W Gao, X Wang, Y Wu - Antiviral therapy, 2005 - journals.sagepub.com
Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease caused
by a novel coronavirus (SARS-CoV), which spread to over 30 countries in early 2003. Until …

Activation of AP-1 signal transduction pathway by SARS coronavirus nucleocapsid protein

R He, A Leeson, A Andonov, Y Li, N Bastien… - Biochemical and …, 2003 - Elsevier
In March 2003, a novel coronavirus was isolated from patients exhibiting atypical
pneumonia and subsequently proven to be the causative agent of the disease now referred …

Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus

M Spiegel, F Weber - Virology Journal, 2006 - Springer
Abstract Background SARS coronavirus (SARS-CoV) is the etiologic agent of the severe
acute respiratory syndrome. SARS-CoV mainly infects tissues of non-lymphatic origin, and …