Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: A survey of recent patent literature
Introduction: Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a
eukaryotic serine-threonine protein kinase belonging to the CMGC group. DYRK1A …
eukaryotic serine-threonine protein kinase belonging to the CMGC group. DYRK1A …
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors as potential therapeutics
DB Jarhad, KK Mashelkar, HR Kim… - Journal of medicinal …, 2018 - ACS Publications
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a member of an
evolutionarily conserved family of protein kinases that belongs to the CMGC group of …
evolutionarily conserved family of protein kinases that belongs to the CMGC group of …
Fragment-derived selective inhibitors of dual-specificity kinases DYRK1A and DYRK1B
D Lee Walmsley, JB Murray, P Dokurno… - Journal of medicinal …, 2021 - ACS Publications
The serine/threonine kinase DYRK1A has been implicated in regulation of a variety of
cellular processes associated with cancer progression, including cell cycle control, DNA …
cellular processes associated with cancer progression, including cell cycle control, DNA …
Function and inhibition of DYRK1A: emerging roles of treating multiple human diseases
Y Yang, X Fan, Y Liu, D Ye, C Liu, H Yang, Z Su… - Biochemical …, 2023 - Elsevier
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is an evolutionarily
conserved protein kinase and the most studied member of the Dual-specificity tyrosine …
conserved protein kinase and the most studied member of the Dual-specificity tyrosine …
DYRK1A inhibitors for disease therapy: Current status and perspectives
Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a conserved
protein kinase that plays essential roles in various biological processes. It is located in the …
protein kinase that plays essential roles in various biological processes. It is located in the …
DYRK1A kinase inhibitors with emphasis on cancer
A Ionescu, F Dufrasne, M Gelbcke… - Mini reviews in …, 2012 - ingentaconnect.com
Various types of cancers (including gliomas, melanomas, and esophageal, pancreas and
non-small-cell lung cancers) display intrinsic resistance to pro-apoptotic stimuli, such as …
non-small-cell lung cancers) display intrinsic resistance to pro-apoptotic stimuli, such as …
DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications
Protein kinases are one of the most studied drug targets in current pharmacological
research, as evidenced by the vast number of kinase-targeting agents enrolled in active …
research, as evidenced by the vast number of kinase-targeting agents enrolled in active …
Mechanism of dual specificity kinase activity of DYRK 1 A
A Walte, K Rüben, R Birner‐Gruenberger… - The FEBS …, 2013 - Wiley Online Library
The function of many protein kinases is controlled by the phosphorylation of a critical
tyrosine residue in the activation loop. Dual specificity tyrosine‐phosphorylation‐regulated …
tyrosine residue in the activation loop. Dual specificity tyrosine‐phosphorylation‐regulated …
Selective macrocyclic inhibitors of DYRK1A/B
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) is a therapeutic
target of interest due to the roles it plays in both neurological diseases and cancer. We …
target of interest due to the roles it plays in both neurological diseases and cancer. We …
Recent developments of protein kinase inhibitors as potential AD therapeutics
V Tell, A Hilgeroth - Frontiers in cellular neuroscience, 2013 - frontiersin.org
Present Alzheimer's disease (AD) therapies suffer from inefficient effects on AD symptoms
like memory or cognition, especially in later states of the disease. Used acteylcholine …
like memory or cognition, especially in later states of the disease. Used acteylcholine …