Pre-mRNA splicing is a fundamental process required for the expression of most metazoan
genes. It is carried out by the spliceosome, which catalyzes the removal of non-coding …

One of the fundamental issues in RNA splicing research is represented by understanding
how the spliceosome can successfully define exons and introns in a huge variety of pre …

Pre-mRNA splicing is an obligatory step required to assemble the vast majority of mRNAs in
eukaryotes. In humans, each gene gives rise to at least two transcripts, with an average 6-8 …

The past year has witnessed refinements in models of spliceosome assembly pathways and
in the understanding of how splicing factors of the serine/arginine-rich (SR) protein family …

Intron removal during pre-mRNA splicing in higher eukaryotes requires the accurate
identification of the two splice sites at the ends of the exons, or exon definition. The …

The first wave of bioinformatic studies that followed genome and complementary DNA
sequencing projects revealed that alternative splicing of messenger RNA precursors (pre …

The majority of eukaryotic messenger RNAs (mRNAs) are initially transcribed as intron-
containing precursor mRNAs (pre-mRNAs). Removal of introns from each pre-mRNA by …

Pre-messengerRNA (mRNA) splicing requires the accurate recognition of splice sites by the
cellular RNA processing machinery. In addition to sequences that comprise the branchpoint …

Alternative pre-mRNA splicing, the differential inclusion or exclusion of portions of a nascent
transcript into the final protein-coding mRNA, is widely recognized to be a ubiquitous …

Alternative pre-mRNA splicing provides a source of vast protein diversity by removing non-
coding sequences (introns) and accurately linking different exonic regions in the correct …