Defining the role of natural killer cells in COVID-19

MJ Lee, CA Blish - Nature immunology, 2023 - nature.com
Natural killer (NK) cells are critical effectors of antiviral immunity. Researchers have
therefore sought to characterize the NK cell response to coronavirus disease 2019 (COVID …

Natural killer cell immunotypes related to COVID-19 disease severity

C Maucourant, I Filipovic, A Ponzetta, S Aleman… - Science …, 2020 - science.org
Understanding innate immune responses in coronavirus disease 2019 (COVID-19) is
important to decipher mechanisms of host responses and interpret disease pathogenesis …

Flattening the COVID-19 curve with natural killer cell based immunotherapies

M Market, L Angka, AB Martel, D Bastin… - Frontiers in …, 2020 - frontiersin.org
Natural Killer (NK) cells are innate immune responders critical for viral clearance and
immunomodulation. Despite their vital role in viral infection, the contribution of NK cells in …

Natural killer cells in antiviral immunity

NK Björkström, B Strunz, HG Ljunggren - Nature Reviews Immunology, 2022 - nature.com
Natural killer (NK) cells play an important role in innate immune responses to viral infections.
Here, we review recent insights into the role of NK cells in viral infections, with particular …

SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D

MJ Lee, MW Leong, A Rustagi, A Beck, L Zeng… - Cell reports, 2022 - cell.com
Natural killer (NK) cells are cytotoxic effector cells that target and lyse virally infected cells;
many viruses therefore encode mechanisms to escape such NK cell killing. Here, we …

NK cells: A double edge sword against SARS-CoV-2

E Masselli, M Vaccarezza, C Carubbi, G Pozzi… - Advances in biological …, 2020 - Elsevier
Natural killer (NK) cells are pivotal effectors of the innate immunity protecting an individual
from microbes. They are the first line of defense against invading viruses, given their …

[HTML][HTML] Natural killer cells in SARS-CoV-2 infection: pathophysiology and therapeutic implications

C Di Vito, F Calcaterra, N Coianiz, S Terzoli… - Frontiers in …, 2022 - frontiersin.org
Natural Killer (NK) cells are lymphocytes of the innate immunity that play a crucial role in the
control of viral infections in the absence of a prior antigen sensitization. Indeed, they display …

Natural killer cells play an important role in virus infection control: Antiviral mechanism, subset expansion and clinical application

W Zuo, X Zhao - Clinical Immunology, 2021 - Elsevier
With the global spread of coronavirus disease 2019 (COVID-19), the important role of
natural killer (NK) cells in the control of various viral infections attracted more interest, via …

[HTML][HTML] Natural killer cells and unconventional T cells in COVID-19

NK Björkström, A Ponzetta - Current Opinion in Virology, 2021 - Elsevier
Highlights•NK cells and unconventional T cells are robustly activated in SARS-CoV-2
infection.•Both populations of cells also home to lung tissue during acute infection.•Severe …

Identification of druggable inhibitory immune checkpoints on Natural Killer cells in COVID-19

O Demaria, J Carvelli, L Batista, ML Thibult… - Cellular & molecular …, 2020 - nature.com
Infection with SARS-COV-2 is the cause of COVID-19 and has generated an unprecedented
health crisis worldwide. While most of the patients experience mild symptoms, around 20 …