Insulin stimulates S100B secretion and these proteins antagonistically modulate brain glucose metabolism

KM Wartchow, AC Tramontina, DF de Souza… - Neurochemical …, 2016 - Springer
Brain metabolism is highly dependent on glucose, which is derived from the blood
circulation and metabolized by the astrocytes and other neural cells via several pathways …

S100B content and secretion decrease in astrocytes cultured in high-glucose medium

P Nardin, F Tramontina, MC Leite… - Neurochemistry …, 2007 - Elsevier
S100B is an astrocyte calcium-binding protein that plays a regulatory role in the cytoskeleton
and cell cycle. Moreover, extracellular S100B, a marker of glial activation in several …

[HTML][HTML] Hyper-glycemia and insulinemia induce morphological changes and modulate secretion of S100B, S100A8, amyloid β 1–40 and amyloid β 1–42, in a model …

A Kubis-Kubiak, B Wiatrak, A Piwowar - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Glucose metabolism in neuronal tissue declines during neurodegenerative disorders in a
progressive, region-specific, and disease-specific manner. Studies have shown that …

Decrease of serum S100B during an oral glucose tolerance test correlates inversely with the insulin response

J Steiner, HG Bernstein, K Schiltz, T Haase… - …, 2014 - Elsevier
Increased S100B serum levels have been considered as a marker of glial pathology, brain
damage, and blood–brain-barrier impairment. However, S100B expression has also been …

S100B Secretion in Astrocytes, Unlike C6 Glioma Cells, Is Downregulated by Lactate

NG Selistre, L Rodrigues, BC Federhen, V Gayger-Dias… - Metabolites, 2023 - mdpi.com
S100B is a calcium-binding protein produced and secreted by astrocytes in response to
various extracellular stimuli. C6 glioma cells are a lineage commonly employed for astroglial …

S100B impairs glycolysis via enhanced poly (ADP-ribosyl) ation of glyceraldehyde-3-phosphate dehydrogenase in rodent muscle cells

K Hosokawa, Y Hamada, A Fujiya… - American Journal …, 2017 - journals.physiology.org
S100 calcium-binding protein B (S100B), a multifunctional macromolecule mainly expressed
in nerve tissues and adipocytes, has been suggested to contribute to the pathogenesis of …

Deficiency of S100B confers resistance to experimental diabetes in mice

F Mohammadzadeh, JN Tsoporis, S Izhar… - Experimental Cell …, 2018 - Elsevier
The calcium binding protein S100B has been implicated in diabetic neuronal and vascular
complications but has not been examined in the development of diabetes. S100B knock out …

Levels of S100B in brain and blood of rats with diabetic ketoacidosis

N Glaser, W Lo, D Tancredi, M Orgain, V Puvenna… - Brain Research, 2015 - Elsevier
Diabetic ketoacidosis (DKA) frequently causes subtle brain injuries in children. Rarely, these
injuries can be severe and life threatening. The physiological processes leading to brain …

The role of S100B in the interaction between adipocytes and macrophages

A Fujiya, H Nagasaki, Y Seino, T Okawa, J Kato… - …, 2014 - Wiley Online Library
Objective The S100 calcium binding protein B (S100B) implicated in brain inflammation acts
via the receptor of advanced glycation end products (RAGE) and is also secreted from …

S100B is expressed in, and released from, OLN-93 oligodendrocytes: influence of serum and glucose deprivation

J Steiner, HG Bernstein, B Bogerts, T Gos… - Neuroscience, 2008 - Elsevier
S100B (member of a family of proteins that are 100% soluble in ammonium sulfate at neutral
pH) has been widely used as astrocyte marker in animal models and in human brain …