Integrated functional genomic analysis enables annotation of kidney genome-wide association study loci
KB Sieber, A Batorsky, K Siebenthall… - Journal of the …, 2019 - journals.lww.com
Background Linking genetic risk loci identified by genome-wide association studies (GWAS)
to their causal genes remains a major challenge. Disease-associated genetic variants are …
to their causal genes remains a major challenge. Disease-associated genetic variants are …
The genetic landscape of renal complications in type 1 diabetes
Diabetes is the leading cause of ESRD. Despite evidence for a substantial heritability of
diabetic kidney disease, efforts to identify genetic susceptibility variants have had limited …
diabetic kidney disease, efforts to identify genetic susceptibility variants have had limited …
Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney
The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and
antihypertensive treatment. However, genetically mediated renal mechanisms underlying …
antihypertensive treatment. However, genetically mediated renal mechanisms underlying …
[HTML][HTML] Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease
Aims/hypothesis Diabetic kidney disease (DKD) is the leading cause of kidney failure and
has a substantial genetic component. Our aim was to identify novel genetic factors and …
has a substantial genetic component. Our aim was to identify novel genetic factors and …
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
DI Chasman, C Fuchsberger, C Pattaro… - Human molecular …, 2012 - academic.oup.com
In conducting genome-wide association studies (GWAS), analytical approaches leveraging
biological information may further understanding of the pathophysiology of clinical traits. To …
biological information may further understanding of the pathophysiology of clinical traits. To …
[HTML][HTML] Urinary metabolites along with common and rare genetic variations are associated with incident chronic kidney disease
We assessed the association between urinary metabolites, genetic variants, and incident
chronic kidney disease (CKD) in the Framingham Offspring cohort. Among the participants …
chronic kidney disease (CKD) in the Framingham Offspring cohort. Among the participants …
[HTML][HTML] Transcriptome-and proteome-wide association studies nominate determinants of kidney function and damage
Background The pathophysiological causes of kidney disease are not fully understood. Here
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …
Mesencephalic Astrocyte–Derived Neurotrophic Factor as a Urine Biomarker for Endoplasmic Reticulum Stress–Related Kidney Diseases
Endoplasmic reticulum (ER) stress and disrupted proteostasis contribute to the
pathogenesis of a variety of glomerular and tubular diseases. Thus, it is imperative to …
pathogenesis of a variety of glomerular and tubular diseases. Thus, it is imperative to …
Genome-wide studies to identify risk factors for kidney disease with a focus on patients with diabetes
F Regele, K Jelencsics, D Shiffman… - Nephrology Dialysis …, 2015 - academic.oup.com
Chronic kidney disease (CKD) affects 10–13% of the general population and diabetic
nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). In addition to …
nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). In addition to …
[HTML][HTML] Genome-wide association study of kidney function decline in individuals of European descent
Genome-wide association studies (GWASs) have identified multiple loci associated with
cross-sectional eGFR, but a systematic genetic analysis of kidney function decline over time …
cross-sectional eGFR, but a systematic genetic analysis of kidney function decline over time …