Disulfiram-based disulfides as narrow-spectrum antibacterial agents

JG Sheppard, KR Frazier, P Saralkar… - Bioorganic & medicinal …, 2018 - Elsevier
Sixteen disulfides derived from disulfiram (Antabuse™) were evaluated as antibacterial
agents. Derivatives with hydrocarbon chains of seven and eight carbons in length exhibited …

[HTML][HTML] The effects of allicin, a reactive sulfur species from garlic, on a selection of mammalian cell lines

MCH Gruhlke, C Nicco, F Batteux, AJ Slusarenko - Antioxidants, 2016 - mdpi.com
Garlic (Allium sativum L.) has been used as a spice and medicinal plant since ancient times.
Garlic produces the thiol-reactive defence substance, allicin, upon wounding. The effects of …

The Organosulfur Chemistry of the Genus Allium – Implications for the Organic Chemistry of Sulfur

E Block - Angewandte Chemie International Edition in English, 1992 - Wiley Online Library
A Cook's tour is presented of the organosulfur chemistry of the genus Allium, as represented,
inter alia, by garlic (Allium sativum L.) and onion (Allium cepa L.). We report on the …

Sulfur containing scaffolds in drugs: synthesis and application in medicinal chemistry

M Feng, B Tang, SH Liang… - Current topics in medicinal …, 2016 - ingentaconnect.com
The impact of the development of sulfur therapeutics is instrumental to the evolution of the
pharmaceutical industry. Sulfur-derived functional groups can be found in a broad range of …

Alkenyl group is responsible for the disruption of microtubule network formation in human colon cancer cell line HT-29 cells

T Hosono, T Hosono-Fukao, K Inada, R Tanaka… - …, 2008 - academic.oup.com
Alk (en) yl trisulfides (R-SSS-R′) are organosulfur compounds produced by crushed garlic
and other Allium vegetables. We found that these compounds exhibit potent anticancer …

Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility

K Ono, T Akaike, T Sawa, Y Kumagai, DA Wink… - Free Radical Biology …, 2014 - Elsevier
Hydrogen sulfide (H 2 S) is an endogenously generated and putative signaling/effector
molecule. Despite its numerous reported functions, the chemistry by which it elicits its …

Fluorescent probes and selective inhibitors for biological studies of hydrogen sulfide-and polysulfide-mediated signaling

Y Takano, H Echizen, K Hanaoka - Antioxidants & redox signaling, 2017 - liebertpub.com
Abstract Significance: Hydrogen sulfide (H2S) plays roles in many physiological processes,
including relaxation of vascular smooth muscles, mediation of neurotransmission, inhibition …

[HTML][HTML] Thiosulfoxide (sulfane) sulfur: new chemistry and new regulatory roles in biology

JI Toohey, AJL Cooper - Molecules, 2014 - mdpi.com
The understanding of sulfur bonding is undergoing change. Old theories on hypervalency of
sulfur and the nature of the chalcogen-chalcogen bond are now questioned. At the same …

Sulfur compounds in foods: an overview

CJ Mussinan, ME Keelan - 1994 - ACS Publications
The importance of sulfur compounds to the flavor and off-flavor characteristics of foods is
well known and continues to be studied. Mechanistic studies have led to a greater …

[HTML][HTML] Using resonance synchronous spectroscopy to characterize the reactivity and electrophilicity of biologically relevant sulfane sulfur

H Li, H Liu, Z Chen, R Zhao, Q Wang, M Ran, Y Xia… - Redox Biology, 2019 - Elsevier
Sulfane sulfur is common inside cells, playing both regulatory and antioxidant roles.
However, there are unresolved issues about its chemistry and biochemistry. We report the …