Cancer stem cells (CSC) present a formidable clinical challenge by escaping therapeutic
intervention and seeding tumors through processes that remain incompletely understood …

The lethality, chemoresistance and metastatic characteristics of cancers are associated with
phenotypically plastic cancer stem cells (CSCs). How the non-cell autonomous signalling …

Pancreatic cancer (PC) is one of the most aggressive malignancies worldwide. Increasing
evidence suggests that the capacity for self-renewal, proliferation, and differentiation of …

Drug resistance and relapse remain key challenges in pancreatic cancer. Here, we have
used RNA sequencing (RNA-seq), chromatin immunoprecipitation (ChIP)-seq, and genome …

Background Pancreatic ductal adenocarcinoma (PDAC) is a profoundly aggressive and fatal
cancer. One of the key factors defining its aggressiveness and resilience against …

Background & Aims Tumor-microenvironment factors and cancer stem cells (CSCs) play a
critical role in the aggressiveness of pancreatic cancer (PC). However, the degree to which …

Pancreatic cancer is one of the most aggressive cancers worldwide due to the resistances to
conventional therapies and early metastasis. Recent research has shown that cancer stem …

Simple Summary Pancreatic cancers are lethal types of cancer. A majority of patients
progress to an advanced and metastatic disease, which remains a major clinical problem …

Background A major challenge in the treatment of pancreatic ductal adenocarcinoma is the
failure of chemotherapy, which is likely due to the presence of the cancer stem cells (CSCs) …

Metastasis and tumor progression are the major cause of death in patients suffering from
pancreatic ductal adenocarcinoma. Tumor growth and especially dissemination are typically …