The spike protein (S) of SARS-CoV-2 has been observed in three distinct pre-fusion
conformations: locked, closed and open. Of these, the locked conformation was not …

The spike (S) protein of SARS-CoV-2 has been observed in three distinct pre-fusion
conformations: locked, closed and open. Of these, the function of the locked conformation …

SARS-CoV-2 spike protein (S) is structurally dynamic and has been observed by cryo-EM to
adopt a variety of prefusion conformations that can be categorized as locked, closed, and …

A single mutation from aspartate to glycine at position 614 has dominated all circulating
variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). D614G …

Abstract Pandemic coronavirus disease 2019 (COVID-19) is caused by the emerging severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for which there are no efficacious …

Substitution for aspartic acid (D) by glycine (G) at position 614 in the spike (S) protein of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to facilitate rapid …

The pre-fusion SARS-CoV-2 spike (S) protein contains S1 and S2 subunits separated by a
protease cleavage site. Upon host attachment mediated by the S1 subunit, S1 detaches and …

The spike protein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
required for cell entry and is the primary focus for vaccine development. In this study, we …

Intervention strategies are urgently needed to control the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) pandemic. The trimeric viral spike (S) protein catalyzes fusion …

The evolution of SARS-CoV-2 variants with increased fitness has been accompanied by
structural changes in the spike (S) proteins that are the major target for the adaptive immune …