Central role of GABA in neuron–glia interactions

M Vélez-Fort, E Audinat, MC Angulo - The Neuroscientist, 2012 - journals.sagepub.com
The major types of glial cells—astrocytes, microglia, and cells of the oligodendroglial
lineage—are known to express functional metabotropic and ionotropic GABA receptors …

Astrocytes as GABA-ergic and GABA-ceptive cells

BE Yoon, J Woo, C Justin Lee - Neurochemical research, 2012 - Springer
GABA (gamma-aminobutyric acid) is considered to be the major inhibitory neurotransmitter
that is synthesized in and released from GABA-ergic neurons in the brain. However, recent …

Oligodendroglial GABAergic signaling: more than inhibition!

X Bai, F Kirchhoff, A Scheller - Neuroscience bulletin, 2021 - Springer
GABA is the main inhibitory neurotransmitter in the CNS acting at two distinct types of
receptor: ligand-gated ionotropic GABAA receptors and G protein-coupled metabotropic …

Is there more to GABA than synaptic inhibition?

DF Owens, AR Kriegstein - Nature Reviews Neuroscience, 2002 - nature.com
In the mature brain, GABA (γ-aminobutyric acid) functions primarily as an inhibitory
neurotransmitter. But it can also act as a trophic factor during nervous system development …

GABA, a forgotten gliotransmitter

MC Angulo, K Le Meur, AS Kozlov, S Charpak… - Progress in …, 2008 - Elsevier
The amino acid γ-aminobutiric acid (GABA) is a major inhibitory transmitter in the vertebrate
central nervous system (CNS) where it can be released by neurons and by glial cells …

Emerging neurotrophic role of GABAB receptors in neuronal circuit development

JL Gaiarsa, C Porcher - Frontiers in cellular neuroscience, 2013 - frontiersin.org
The proper development of highly organized structures in the central nervous system is a
complex process during which key events–neurogenesis, migration, growth, differentiation …

Refining the roles of GABAergic signaling during neural circuit formation

CJ Akerman, HT Cline - Trends in neurosciences, 2007 - cell.com
Our understanding of the role of GABA signaling in circuit development is rapidly expanding.
Here, we review three recent refinements in our understanding of the diverse roles that …

Astrocytic GABA receptors

DD Fraser, LA Mudrick‐Donnon, BA Macvicar - Glia, 1994 - Wiley Online Library
GABA receptors are distributed widely throughout the central nervous system on a variety of
cell types. It has become increasingly clear that astrocytes, both in cell culture and tissue …

GABA release from astrocytes in health and disease

W Kilb, S Kirischuk - International Journal of Molecular Sciences, 2022 - mdpi.com
Astrocytes are the most abundant glial cells in the central nervous system (CNS) mediating a
variety of homeostatic functions, such as spatial K+ buffering or neurotransmitter reuptake. In …

Expression and function of GABA receptors in myelinating cells

MP Serrano-Regal, L Bayón-Cordero… - Frontiers in cellular …, 2020 - frontiersin.org
Myelin facilitates the fast transmission of nerve impulses and provides metabolic support to
axons. Differentiation of oligodendrocyte progenitor cells (OPCs) and Schwann cell (SC) …