The anti-inflammatory and immunomodulatory potential of braylin: Pharmacological properties and mechanisms by in silico, in vitro and in vivo approaches

RF Espirito-Santo, CS Meira, RS Costa… - PLoS …, 2017 - journals.plos.org
Braylin belongs to the group of natural coumarins, a group of compounds with a wide range
of pharmacological properties. Here we characterized the pharmacological properties of …

Synthesis of carvone derivatives and in silico and in vitro screening of anti-inflammatory activity in murine macrophages

G Moço, C Sousa, A Capitão, SS MacKinnon… - International Journal of …, 2023 - mdpi.com
The chemical modification of natural compounds is a promising strategy to improve their
frequently poor bioavailability and low potency. This study aimed at synthesizing chemical …

In vitro Anti‐Inflammatory Potency of Sanguinarine and Chelerythrine via Interaction with Glucocorticoid Receptor

J Zhang, Y Liang, L Ren, T Zhang - eFood, 2020 - Wiley Online Library
As quaternary benzo [c] phenanthridine alkaloids, sanguinarine and chelerythrine possess
multiple biological activities including anti‐inflammatory effects. They have been confirmed …

Anti-inflammatory action of betulin and its potential as a dissociated glucocorticoid receptor modulator

L Ren, S Niu, Y Sun, Y Liang, J Zhao, T Zhang… - Food and Chemical …, 2021 - Elsevier
Although the medical application of betulin has been presented in previous studies, the
potential mechanism of the anti-inflammatory action of betulin should be further investigated …

Sulforaphane mitigates mast cell-mediated allergic inflammatory reactions in in silico simulation and in vitro models

M Jeon, J Lee, HK Lee, SJ Cho, JH Lim… - …, 2020 - Taylor & Francis
Objectives: Sulforaphane, a major ingredient isolated from Brassica oleracea var. italica
(broccoli), is known to exhibit anti-inflammatory, anti-cancer, and anti-diabetic effects. In this …

[PDF][PDF] In silico interaction of Berberine with some immunomodulatory targets: A docking analysis

A Ganeshpurkar, A Chaturvedi… - Indian Journal of …, 2022 - op.niscpr.res.in
Plant, mineral, and animal products have been utilized as medications from the beginning of
time to cure a variety of ailments. Use of medicinal herbs to modulate immune function has a …

In silico and in vitro study of the bromelain-phytochemical complex inhibition of phospholipase A2 (PLA2)

F Mohamed Tap, FA Abd Majid, HF Ismail, TS Wong… - Molecules, 2018 - mdpi.com
Phospholipase A2 (Pla2) is an enzyme that induces inflammation, making Pla2 activity an
effective approach to reduce inflammation. Therefore, investigating natural compounds for …

Semi-mechanism-based pharmacodynamic model for the anti-inflammatory effect of baicalein in LPS-stimulated RAW264. 7 macrophages

L Xiang, YF Hu, JS Wu, L Wang, WG Huang… - Frontiers in …, 2018 - frontiersin.org
Monitoring of the inhibition of TNF-α, IL-6, iNOS, and NO is used to effectively evaluate anti-
inflammatory drugs. Baicalein was found to have good anti-inflammatory activities, but its …

Glucocorticoid receptor-mediated alleviation of inflammation by berberine: in vitro, in silico and in vivo investigations

Y Liang, T Zhang, J Zhao, C Li, H Zou, F Li, J Zhang… - Food & Function, 2021 - pubs.rsc.org
As a natural dietary ingredient, berberine possesses multiple biological activities including
anti-inflammatory effects. In this work, glucocorticoid receptor (GR)-mediated alleviation of …

[HTML][HTML] Anti-inflammatory effect and potential mechanism of betulinic acid on λ-carrageenan-induced paw edema in mice

Z Ou, J Zhao, L Zhu, L Huang, Y Ma, C Ma… - Biomedicine & …, 2019 - Elsevier
Abstract λ-Carrageenan (Carr), a seaweed polysaccharide, is used as a proinflammatory
agent in research. Betulinic acid (BA), a naturally occurring pentacyclic triterpenoid, exerts …