Cell and animal models of SARS-CoV-2 pathogenesis and immunity

SR Leist, A Schäfer… - Disease models & …, 2020 - journals.biologists.com
The spread of the novel virus SARS coronavirus 2 (SARS-CoV-2) was explosive, with cases
first identified in December 2019, and> 22 million people infected and> 775,000 deaths as …

A mouse model of SARS-CoV-2 infection and pathogenesis

SH Sun, Q Chen, HJ Gu, G Yang, YX Wang… - Cell host & …, 2020 - cell.com
Since December 2019, a novel coronavirus SARS-CoV-2 has emerged and rapidly spread
throughout the world, resulting in a global public health emergency. The lack of vaccine and …

Mechanisms of SARS-CoV-2 transmission and pathogenesis

AG Harrison, T Lin, P Wang - Trends in immunology, 2020 - cell.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marks
the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 …

Experimental models of SARS-CoV-2 infection: possible platforms to study COVID-19 pathogenesis and potential treatments

S Pandamooz, B Jurek, CP Meinung… - Annual review of …, 2022 - annualreviews.org
In December 2019, a novel coronavirus crossed species barriers to infect humans and was
effectively transmitted from person to person, leading to a worldwide pandemic …

Animal models for SARS‐CoV‐2 infection and pathology

Z Bi, W Hong, J Yang, S Lu, X Peng - MedComm, 2021 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the etiology of
coronavirus disease 2019 (COVID‐19) pandemic. Current variants including Alpha, Beta …

A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies

AO Hassan, JB Case, ES Winkler, LB Thackray… - Cell, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic
with millions of human infections. One limitation to the evaluation of potential therapies and …

Generation of a broadly useful model for COVID-19 pathogenesis, vaccination, and treatment

J Sun, Z Zhuang, J Zheng, K Li, RLY Wong, D Liu… - Cell, 2020 - cell.com
Summary COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with> 4,000,000
confirmed cases worldwide and> 290,000 deaths as of May 15, 2020. It is critical that …

Animal models for SARS-CoV-2

CY Lee, AC Lowen - Current opinion in virology, 2021 - Elsevier
Since its first detection in December 2019, severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) has rapidly spread worldwide, resulting in over 79.2 million documented …

SARS-CoV-2 immunity in animal models

Z Chen, Y Yuan, Q Hu, A Zhu, F Chen, S Li… - Cellular & molecular …, 2024 - nature.com
The COVID-19 pandemic, which was caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has become a worldwide health crisis due to its …

Animal and translational models of SARS-CoV-2 infection and COVID-19

MD Johansen, A Irving, X Montagutelli, MD Tate… - Mucosal …, 2020 - nature.com
COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical
community is in a race to define and develop effective preventions and treatments. The …