[PDF][PDF] Advances in the treatment of cytomegalovirus

BA Krishna, MR Wills, JH Sinclair - British Medical Bulletin, 2019 - academic.oup.com
Background Human cytomegalovirus (HCMV) is a threat to immunologically weak patients.
HCMV cannot yet be eliminated with a vaccine, despite recent advances. Sources of data …

Vaccine strategies against human cytomegalovirus infection

J Zhong, R Khanna - Expert Review of Anti-Infective Therapy, 2007 - Taylor & Francis
Human cytomegalovirus (HCMV) disease is a major cause of morbidity and mortality in
neonates and immunocompromised populations, such as transplant recipients and HIV …

Development of a cytomegalovirus vaccine: lessons from recent clinical trials

E Gonczol, S Plotkin - Expert opinion on biological therapy, 2001 - Taylor & Francis
Cytomegalovirus-caused diseases are preventable. We believe that both neutralising
antibodies and cell-mediated immunity are necessary for prevention. Of the CMV proteins …

Development of a vaccine against human cytomegalovirus: advances, barriers, and implications for the clinical practice

S Scarpini, F Morigi, L Betti, A Dondi, C Biagi, M Lanari - Vaccines, 2021 - mdpi.com
Human cytomegalovirus (hCMV) is one of the most common causes of congenital infection
in the post-rubella era, representing a major public health concern. Although most cases are …

Cytomegalovirus vaccine development

MR Schleiss - Human Cytomegalovirus, 2008 - Springer
Although infection with human cytomegalovirus (HCMV) is ubiquitous and usually
asymptomatic, there are individuals at high risk for serious HCMV disease. These include …

[HTML][HTML] Summary of the II international symposium on cytomegalovirus

MD De Jong, GJ Galasso, B Gazzard, PD Griffiths… - Antiviral research, 1998 - Elsevier
Human cytomegalovirus (HCMV) is a highly species-specific DNA virus belonging to the
Betaherpesvirinae subfamily of the herpesviridae family. Like other herpesviruses, primary …

Progress on pursuit of human cytomegalovirus vaccines for prevention of congenital infection and disease

TM Fu, Z An, D Wang - Vaccine, 2014 - Elsevier
Congenital infection of human cytomegalovirus (HCMV) is the leading cause of childhood
hearing loss and mental retardation. Unfortunately, a preventive vaccine remains elusive …

Human cytomegalovirus vaccine: time to look for alternative options

R Khanna, DJ Diamond - Trends in molecular medicine, 2006 - cell.com
In 1999, the Institute of Medicine (IOM) of the National Academy of Sciences (USA) assigned
the highest priority for a vaccine to prevent congenital human cytomegalovirus (HCMV) …

Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments

MK Gandhi, R Khanna - The Lancet infectious diseases, 2004 - thelancet.com
After initial infection, human cytomegalovirus remains in a persistent state with the host.
Immunity against the virus controls replication, although intermitent viral shedding can still …

[HTML][HTML] Cytomegalovirus vaccines under clinical development

MR Schleiss - Journal of virus eradication, 2016 - Elsevier
Congenital cytomegalovirus (CMV) infection is the most common infectious cause of
disability in newborn infants. CMV also causes serious disease in solid organ (SOT) and …