Publisher Summary Although the direct relationship between DNA double-strand breaks
and cell survival has not yet been established experimentally in eukaryotic cells, this chapter …

A large number of reports suggest that DNA double-strand breaks (DSB) play a major role in
the radiation-induced killing of mammalian cells. However, the arguments supporting the …

Recent data suggest that the differences in radiosensitivity between cell lines can be related
to differences in dsb induction (Radford 1986a). In the light of this we have set out to assess …

An important question in radiobiology is the relationship between primary DNA damage and
chromosomal aberrations. What determines the chromosomal aberration frequency …

TN-368 lepidopteran insect cells are on the order of 100 times more resistant to the lethal
effects of ionizing radiation than cultured mammalian cells. DNA double-strand breaks …

We examined the relationship between γ-ray-induced DNA double-strand breaks (dsb) and
cell lethality in five mammalian cell lines differing in radiosensitivity; HA-1, HMV-I, L5178Y …

The model of radiation action that is presented relates the surviving fraction of irradiated
cells to unrepaired DNA double-strand breaks (DSBs). The following assumptions are made …

Ionizing radiation produces many types of DNA lesions that have the potential of killing cells.
The lethal lesion is probably an unrepaired or misrepaired double-strand break produced as …

As the first stage in the development of a comprehensive explanation of radiation effects in
mammalian cells, a general model for DNA damage formation and repair is described. This …

The prevailing hypothesis on the mechanism of radiation-induced cell killing identifies the
genetic material deoxyribonucleic acid (DNA) as the most important subcellular target at …