[HTML][HTML] Effects of Olig2-overexpressing neural stem cells and myelin basic protein-activated T cells on recovery from spinal cord injury

JG Hu, L Shen, R Wang, QY Wang, C Zhang, J Xi… - …, 2012 - Elsevier
Neural stem cell (NSC) transplantation is a major focus of current research for treatment of
spinal cord injury (SCI). However, it is very important to promote the survival and …

Transplantation of human neural stem cells transduced with Olig2 transcription factor improves locomotor recovery and enhances myelination in the white matter of rat …

DH Hwang, BG Kim, EJ Kim, SI Lee, IS Joo… - BMC neuroscience, 2009 - Springer
Background Contusive spinal cord injury is complicated by a delayed loss of
oligodendrocytes, resulting in chronic progressive demyelination. Therefore, transplantation …

Cell-based delivery of interleukin-13 directs alternative activation of macrophages resulting in improved functional outcome after spinal cord injury

D Dooley, E Lemmens, T Vangansewinkel, D Le Blon… - Stem cell reports, 2016 - cell.com
The therapeutic effects of mesenchymal stem cell (MSC) transplantation following spinal
cord injury (SCI) to date have been limited. Therefore, we aimed to enhance the …

Transplantation of Wnt4‐modified neural stem cells mediate M2 polarization to improve inflammatory micro‐environment of spinal cord injury

B Pan, X Wu, X Zeng, J Chen, W Zhang… - Cell …, 2023 - Wiley Online Library
Neural stem cells (NSCs) transplantation has been considered as a potential strategy to
reconnect the neural circuit after spinal cord injury (SCI) but the therapeutic effect was still …

Differential effects of myelin basic protein-activated Th1 and Th2 cells on the local immune microenvironment of injured spinal cord

JG Hu, LL Shi, YJ Chen, XM Xie, N Zhang, AY Zhu… - Experimental …, 2016 - Elsevier
Myelin basic protein (MBP) activated T cells (MBP-T) play an important role in the damage
and repair process of the central nervous system (CNS). However, whether these cells play …

Polarized macrophages have distinct roles in the differentiation and migration of embryonic spinal-cord-derived neural stem cells after grafting to injured sites of spinal …

K Zhang, J Zheng, G Bian, L Liu, Q Xue, F Liu, C Yu… - Molecular Therapy, 2015 - cell.com
Spinal cord injury (SCI) frequently provokes serious detrimental outcomes because
neuronal regeneration is limited in the central nervous system (CNS). Thus, the creation of a …

Neural stem cell-conditioned medium suppresses inflammation and promotes spinal cord injury recovery

Z Cheng, DB Bosco, L Sun, X Chen, Y Xu… - Cell …, 2017 - journals.sagepub.com
Spinal cord injury (SCI) causes functional impairment as a result of the initial injury followed
by secondary injury mechanism. SCI provokes an inflammatory response that causes …

Anti-inflammatory mechanism of neural stem cell transplantation in spinal cord injury

Z Cheng, W Zhu, K Cao, F Wu, J Li, G Wang… - International journal of …, 2016 - mdpi.com
Neural stem cell (NSC) transplantation has been proposed to promote functional recovery
after spinal cord injury. However, a detailed understanding of the mechanisms of how NSCs …

Functional recovery after spinal cord injury in mice through activation of microglia and dendritic cells after IL‐12 administration

M Yaguchi, S Ohta, Y Toyama… - Journal of …, 2008 - Wiley Online Library
We have previously reported that the transplantation of dendritic cells (DCs) brings about
functional recovery after spinal cord injury in mice through the activation of endogenous …

Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative …

T Gao, F Huang, W Wang, Y Xie, B Wang - Cellular & molecular biology …, 2022 - Springer
Background After spinal cord injury (SCI), dysregulated or nonresolving inflammatory
processes can severely disturb neuronal homeostasis and drive neurodegeneration …