[HTML][HTML] Cytokine storm in tuberculosis and IL-6 involvement

FG Boni, I Hamdi, LM Koundi, K Shrestha… - Infection, Genetics and …, 2022 - Elsevier
Tuberculosis is probably the most seasoned illness of the humanity. Intricacies or
subsequent death emerging from these infections are frequently connected with cytokine …

Advances on the Role and Applications of Interleukin-1 in Tuberculosis

D Silvério, R Gonçalves, R Appelberg, M Saraiva - MBio, 2021 - Am Soc Microbiol
ABSTRACT Interleukin-1 (IL-1) is a key player in the immune response to pathogens due to
its role in promoting inflammation and recruiting immune cells to the site of infection. In …

[HTML][HTML] Interleukin-10 family and tuberculosis: an old story renewed

AE Abdalla, N Lambert, X Duan… - International journal of …, 2016 - ncbi.nlm.nih.gov
Abstract The interleukin-10 (IL-10) family of cytokines consists of six immune mediators,
namely IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. IL-10, IL-22, IL-24 and IL-26 are critical for …

The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis

AM Cooper, SA Khader - Immunological reviews, 2008 - Wiley Online Library
Tuberculosis (TB) results from an interaction between a potent immune response and a
chronically persistent pathogen. The ability of Mycobacterium tuberculosis (Mtb) to induce a …

Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection

DM Higgins, J Sanchez-Campillo, AG Rosas-Taraco… - Tuberculosis, 2009 - Elsevier
Failure of mice to produce IL-10 has no effect on the bacterial burden of Mycobacterium
tuberculosis infection in the lungs over the first 4–5 months of the disease. We show here …

Interleukin-12 and tuberculosis: an old story revisited

AM Cooper, A Solache, SA Khader - Current opinion in immunology, 2007 - Elsevier
Our understanding of the role of interleukin (IL)-12 in controlling tuberculosis has expanded
because of increased interest in other members of the IL-12 family of cytokines. Recent data …

Lethal tuberculosis in interleukin-6-deficient mutant mice

CH Ladel, C Blum, A Dreher, K Reifenberg… - Infection and …, 1997 - Am Soc Microbiol
Tuberculosis is a chronic infectious disease which causes major health problems globally.
Acquired resistance is mediated by T lymphocytes and executed by activated macrophages …

Interleukin-11 Drives Early Lung Inflammation during Mycobacterium tuberculosis Infection in Genetically Susceptible Mice

MA Kapina, GS Shepelkova, VG Avdeenko… - PloS one, 2011 - journals.plos.org
IL-11 is multifunctional cytokine whose physiological role in the lungs during pulmonary
tuberculosis (TB) is poorly understood. Here, using in vivo administration of specific …

Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice

GL Beamer, DK Flaherty, BD Assogba… - The Journal of …, 2008 - journals.aai.org
IL-10 is a potent immunomodulatory cytokine that affects innate and acquired immune
responses. The immunological consequences of IL-10 production during pulmonary …

[HTML][HTML] T cell–derived IL-10 impairs host resistance to Mycobacterium tuberculosis infection

L Moreira-Teixeira, PS Redford… - The Journal of …, 2017 - journals.aai.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis infection, is a leading cause of
mortality and morbidity, causing∼ 1.5 million deaths annually. CD4+ T cells and several …