[HTML][HTML] Innate immune response to SARS-CoV-2 infection: From cells to soluble mediators

D Ricci, MP Etna, F Rizzo, S Sandini, M Severa… - International journal of …, 2021 - mdpi.com
The vulnerability of humankind to SARS-CoV-2 in the absence of a pre-existing immunity,
the unpredictability of the infection outcome, and the high transmissibility, broad tissue …

[HTML][HTML] Severe COVID-19 is characterized by the co-occurrence of moderate cytokine inflammation and severe monocyte dysregulation

B Bonnet, J Cosme, C Dupuis, E Coupez, M Adda… - …, 2021 - thelancet.com
Background SARS-CoV-2 has been responsible for considerable mortality worldwide, owing
in particular to pulmonary failures such as ARDS, but also to other visceral failures and …

[HTML][HTML] Immunopathogenesis and treatment of cytokine storm in COVID-19

JS Kim, JY Lee, JW Yang, KH Lee, M Effenberger… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-
inflammation, acute respiratory distress syndrome, and multiple organ failure. Cytokine …

[HTML][HTML] Chemokines and chemokine receptors during COVID-19 infection

BA Khalil, NM Elemam, AA Maghazachi - Computational and structural …, 2021 - Elsevier
Chemokines are crucial inflammatory mediators needed during an immune response to
clear pathogens. However, their excessive release is the main cause of hyperinflammation …

[HTML][HTML] COVID-19: towards understanding of pathogenesis

W Cao, T Li - Cell research, 2020 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) is spreading rapidly. Although the
cause was quickly identified as a new coronavirus named SARS-CoV-2, our knowledge of …

[HTML][HTML] The pathogenesis of coronavirus-19 disease

AC Borczuk, RK Yantiss - Journal of biomedical science, 2022 - Springer
Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) is the causal
agent of coronavirus disease-2019 (COVID-19), a systemic illness characterized by variably …

[HTML][HTML] Harnessing the immune system to overcome cytokine storm and reduce viral load in COVID-19: a review of the phases of illness and therapeutic agents

S Khadke, N Ahmed, N Ahmed, R Ratts, S Raju… - Virology journal, 2020 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is caused by Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, previously named 2019-nCov), a novel …

The amount of cytokine-release defines different shades of Sars-Cov2 infection

S Bindoli, M Felicetti, P Sfriso… - … Biology and Medicine, 2020 - journals.sagepub.com
The recent outbreak of coronavirus disease (COVID 19), spreading from China all around
the world in early 2020, has led scientists to investigate the immuno-mediated mechanisms …

COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?

MJ Ombrello, GS Schulert - Translational Research, 2021 - Elsevier
Although interest in “cytokine storms” has surged over the past decade, it was massively
amplified in 2020 when it was suggested that a subset of patients with COVID-19 developed …

Monocytes and macrophages in COVID-19: Friends and foes

S Meidaninikjeh, N Sabouni, HZ Marzouni, S Bengar… - Life sciences, 2021 - Elsevier
The COVID-19 is a novel infectious disease caused by SARS-CoV-2 and is known as a
pandemic emergency that has led to a high rate of mortality throughout the world. Evidence …