Chalcones form a class of compounds that belong to the flavonoid family and are widely
distributed in plants. Their simple structure and the ease of preparation make chalcones …

The potential of natural and synthetic chalcones as therapeutic leads against different
pathological conditions has been investigated for several years, and this class of …

The available drugs for treating Leishmaniasis and American trypanosomiasis have high
toxicity and multiple side effects, among other problems. More effective and less toxic …

Chalcones display a broad spectrum of pharmacological activities. Herein, a series of 2'-
hydroxy methoxylated chalcones was synthesized and evaluated towards Trypanosoma …

All currently used first-line and second-line drugs for the treatment of leishmaniasis exhibit
several drawbacks including toxicity, high costs and route of administration. Furthermore …

Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal
agents. All tested compounds caused concentration-dependent inhibition of the in vitro …

Synthesis of a cytotoxic dihydrochalcone, first isolated from a traditional Amazonian
medicinal plant Iryanthera juruensis Warb (Myristicaceae), followed by a comprehensive …

Despite clinical importance of leishmaniasis, an infectious disease that affects 12 thousand
million people in 88 countries, the treatment is still unsatisfactory due to its limited efficacy …

Leishmaniases are endemic diseases in tropical and sub-tropical regions of the world and
are considered by the World Health Organization (WHO) to be among the six most important …

With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a
cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in …