Molecular logic of cellular diversification in the mouse cerebral cortex

DJ Di Bella, E Habibi, RR Stickels, G Scalia, J Brown… - Nature, 2021 - nature.com
The mammalian cerebral cortex has an unparalleled diversity of cell types, which are
generated during development through a series of temporally orchestrated events that are …

[HTML][HTML] An atlas of cortical arealization identifies dynamic molecular signatures

A Bhaduri, C Sandoval-Espinosa, M Otero-Garcia, I Oh… - Nature, 2021 - nature.com
The human brain is subdivided into distinct anatomical structures, including the neocortex,
which in turn encompasses dozens of distinct specialized cortical areas. Early …

[HTML][HTML] Single-cell epigenomics reveals mechanisms of human cortical development

RS Ziffra, CN Kim, JM Ross, A Wilfert, TN Turner… - Nature, 2021 - nature.com
During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …

[HTML][HTML] The molecular cytoarchitecture of the adult mouse brain

J Langlieb, NS Sachdev, KS Balderrama, NM Nadaf… - Nature, 2023 - nature.com
The function of the mammalian brain relies upon the specification and spatial positioning of
diversely specialized cell types. Yet, the molecular identities of the cell types and their …

Molecular architecture of the developing mouse brain

G La Manno, K Siletti, A Furlan, D Gyllborg, E Vinsland… - Nature, 2021 - nature.com
The mammalian brain develops through a complex interplay of spatial cues generated by
diffusible morphogens, cell–cell interactions and intrinsic genetic programs that result in …

[HTML][HTML] A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain

Z Yao, CTJ van Velthoven, M Kunst, M Zhang… - Nature, 2023 - nature.com
The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …

Chromatin accessibility dynamics in a model of human forebrain development

AE Trevino, N Sinnott-Armstrong, J Andersen, SJ Yoon… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex is responsible for higher-order functions in the nervous
system and has undergone substantial expansion in size in primates. The development of …

Transcriptional landscape of the prenatal human brain

JA Miller, SL Ding, SM Sunkin, KA Smith, L Ng… - Nature, 2014 - nature.com
The anatomical and functional architecture of the human brain is mainly determined by
prenatal transcriptional processes. We describe an anatomically comprehensive atlas of the …

[HTML][HTML] Single-cell transcriptomic analysis of mouse neocortical development

L Loo, JM Simon, L Xing, ES McCoy… - Nature …, 2019 - nature.com
The development of the mammalian cerebral cortex depends on careful orchestration of
proliferation, maturation, and migration events, ultimately giving rise to a wide variety of …

An anatomically comprehensive atlas of the adult human brain transcriptome

MJ Hawrylycz, ES Lein, AL Guillozet-Bongaarts… - Nature, 2012 - nature.com
Neuroanatomically precise, genome-wide maps of transcript distributions are critical
resources to complement genomic sequence data and to correlate functional and genetic …