Genetic determinants of cognition are poorly characterized, and their relationship to genes
that confer risk for neurodevelopmental disease is unclear. Here we performed a systems …

Multivariate genetic research suggests that a single set of genes affects most cognitive
abilities and disabilities. This finding already has far-reaching implications for cognitive …

Modern genetic studies indicate that human brain evolution is driven primarily by changes in
gene regulation, which requires understanding the biological function of largely non-coding …

Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Methods integrating genetics with transcriptomic reference panels prioritize risk genes and
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …

Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …

Compelling evidence suggests that human cognitive function is strongly influenced by
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …

Background Mouse models have allowed for the direct interrogation of genetic effects on
molecular, physiological, and behavioral brain phenotypes. However, it is unknown to what …

The development and function of our brain are governed by a genetic blueprint, which
reflects dynamic changes over the history of evolution. Recent progress in genetics and …

Cognitive deficits are known to be related to most forms of psychopathology. Here, we
perform local genetic correlation analysis as a means of identifying independent segments …