The structure and function of G-protein-coupled receptors

DM Rosenbaum, SGF Rasmussen, BK Kobilka - Nature, 2009 - nature.com
G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to
hormones, neurotransmitters and environmental stimulants, and so have great potential as …

A new era of GPCR structural and chemical biology

S Granier, B Kobilka - Nature chemical biology, 2012 - nature.com
G protein–coupled receptors (GPCRs) are versatile molecular machines that regulate the
majority of physiological responses to chemically diverse hormones and neurotransmitters …

Molecular signatures of G-protein-coupled receptors

AJ Venkatakrishnan, X Deupi, G Lebon, CG Tate… - Nature, 2013 - nature.com
G-protein-coupled receptors (GPCRs) are physiologically important membrane proteins that
sense signalling molecules such as hormones and neurotransmitters, and are the targets of …

Structure and function of peptide-binding G protein-coupled receptors

F Wu, G Song, C de Graaf, RC Stevens - Journal of Molecular Biology, 2017 - Elsevier
G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and are
important human drug targets. Of the 826 human GPCRs, 118 of them recognize …

[HTML][HTML] Structural studies of G protein-coupled receptors

D Zhang, Q Zhao, B Wu - Molecules and cells, 2015 - Elsevier
G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically
important membrane protein family that recognizes a variety of environmental stimuli, and …

Structure-function of the G protein–coupled receptor superfamily

V Katritch, V Cherezov… - Annual review of …, 2013 - annualreviews.org
During the past few years, crystallography of G protein–coupled receptors (GPCRs) has
experienced exponential growth, resulting in the determination of the structures of 16 distinct …

New G-protein-coupled receptor crystal structures: insights and limitations

B Kobilka, GFX Schertler - Trends in pharmacological sciences, 2008 - cell.com
G-protein-coupled receptors (GPCRs) constitute a large family of structurally similar proteins
that respond to a chemically diverse array of physiological and environmental stimulants …

[HTML][HTML] Assembly of a GPCR-G protein complex

Y Du, NM Duc, SGF Rasmussen, D Hilger, X Kubiak… - Cell, 2019 - cell.com
The activation of G proteins by G protein-coupled receptors (GPCRs) underlies the majority
of transmembrane signaling by hormones and neurotransmitters. Recent structures of GPCR …

Structural insights into emergent signaling modes of G protein–coupled receptors

I Sutkeviciute, JP Vilardaga - Journal of Biological Chemistry, 2020 - ASBMB
G protein–coupled receptors (GPCRs) represent the largest family of cell membrane
proteins, with> 800 GPCRs in humans alone, and recognize highly diverse ligands, ranging …

Structural basis for G protein-coupled receptor activation

A Manglik, AC Kruse - Biochemistry, 2017 - ACS Publications
G protein-coupled receptors (GPCRs) are critical regulators of human physiology and make
up the largest single class of therapeutic drug targets. Although GPCRs regulate highly …