Boosting the power of schizophrenia genetics by leveraging new statistical tools
OA Andreassen, WK Thompson… - Schizophrenia …, 2014 - academic.oup.com
Genome-wide association studies (GWAS) have identified a large number of gene variants
associated with schizophrenia, but these variants explain only a small portion of the …
associated with schizophrenia, but these variants explain only a small portion of the …
Genome-wide association studies of schizophrenia: does bigger lead to better results?
SE Bergen, TL Petryshen - Current opinion in psychiatry, 2012 - journals.lww.com
Identifying the genetic underpinnings of complex diseases offers insight into the etiological
mechanisms leading to manifestation of the disease. New and more effective treatments for …
mechanisms leading to manifestation of the disease. New and more effective treatments for …
New statistical approaches exploit the polygenic architecture of schizophrenia—implications for the underlying neurobiology
Highlights•Schizophrenia is highly polygenic with much missing heritability.•New statistical
tools are tailored to polygenic investigation of GWAS data.•Extensive enrichment is present …
tools are tailored to polygenic investigation of GWAS data.•Extensive enrichment is present …
Genetics of schizophrenia: ready to translate?
Abstract Purpose of Review This is an era where we have significantly advanced the
understanding of the genetic architecture of schizophrenia. In this review, we consider how …
understanding of the genetic architecture of schizophrenia. In this review, we consider how …
Integrated post-GWAS analysis sheds new light on the disease mechanisms of schizophrenia
Schizophrenia is a severe mental disorder with a large genetic component. Recent genome-
wide association studies (GWAS) have identified many schizophrenia-associated common …
wide association studies (GWAS) have identified many schizophrenia-associated common …
Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in …
Genome-wide association (GWAS) analyses have identified susceptibility loci for many
diseases, but most risk for any complex disorder remains unattributed. There is therefore …
diseases, but most risk for any complex disorder remains unattributed. There is therefore …
The impact of clinical heterogeneity in schizophrenia on genomic analyses
SG Liang, TA Greenwood - Schizophrenia research, 2015 - Elsevier
Though clinically useful, the diagnostic systems currently employed are not well equipped to
capture the substantial clinical heterogeneity observed for most psychiatric disorders, as …
capture the substantial clinical heterogeneity observed for most psychiatric disorders, as …
A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation
WTCC Consortium… - Biological …, 2014 - Elsevier
Background Genome-wide association studies (GWAS) have identified several loci
associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis …
associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis …
Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies
Objective: The authors sought to demonstrate that schizophrenia is a heterogeneous group
of heritable disorders caused by different genotypic networks that cause distinct clinical …
of heritable disorders caused by different genotypic networks that cause distinct clinical …
The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare …
BJ Mowry, J Gratten - Molecular psychiatry, 2013 - nature.com
After decades of halting progress, recent large genome-wide association studies (GWAS)
are finally shining light on the genetic architecture of schizophrenia. The picture emerging is …
are finally shining light on the genetic architecture of schizophrenia. The picture emerging is …