Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs

T Nakanishi, I Tamai - Drug metabolism and pharmacokinetics, 2012 - jstage.jst.go.jp
There is convincing evidence that many organic anion transporting polypeptide (OATP)
transporters influence the pharmacokinetics and pharmacological efficacy of their substrate …

Impact of genetic variation in OATP transporters to drug disposition and response

IY Gong, RB Kim - Drug metabolism and pharmacokinetics, 2013 - jstage.jst.go.jp
There has been remarkable progress during the past decade in understanding of how
genetic variations in drug metabolizing enzymes and transporters contribute to observed …

Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption

Y Shitara, K Maeda, K Ikejiri, K Yoshida… - … & drug disposition, 2013 - Wiley Online Library
Organic anion transporting polypeptide (OATP) family transporters accept a number of drugs
and are increasingly being recognized as important factors in governing drug and …

Role of OATP transporters in the disposition of drugs

M Niemi - Pharmacogenomics, 2007 - Taylor & Francis
During recent years, it has become increasingly recognized that drug transporters play
important roles in drug absorption and disposition. Organic anion transporting polypeptides …

Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination

NF Smith, WD Figg, A Sparreboom - Expert opinion on drug …, 2005 - Taylor & Francis
Members of the organic anion transporting polypeptide (OATP) family are responsible for the
cellular uptake of a broad range of endogenous compounds and xenobiotics in multiple …

Impact of OATP transporters on pharmacokinetics

A Kalliokoski, M Niemi - British journal of pharmacology, 2009 - Wiley Online Library
Membrane transporters are now recognized as important determinants of the
transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a …

Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity

UI Schwarz, HEM zu Schwabedissen… - Pharmacogenetics …, 2011 - journals.lww.com
Objective The uptake carrier organic anion-transporting polypeptide 1B3 (OATP1B3, gene
SLCO1B3) is involved in the hepatic clearance of xenobiotics including statins, taxanes, and …

The functional consequences of genetic variations in transporter genes encoding human organic anion-transporting polypeptide family members

A Seithel, H Glaeser, MF Fromm… - Expert opinion on drug …, 2008 - Taylor & Francis
It is increasingly recognised that uptake transporters of the organic anion-transporting
polypeptide (OATP) family play important roles in drug absorption, distribution and excretion …

Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake

M Niemi, MK Pasanen, PJ Neuvonen - Pharmacological reviews, 2011 - ASPET
The importance of membrane transporters for drug pharmacokinetics has been increasingly
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …

Pharmacogenomics of organic anion-transporting polypeptides (OATP)

RG Tirona, RB Kim - Advanced drug delivery reviews, 2002 - Elsevier
The organic anion-transporting polypeptides (OATP) represent a family of proteins
responsible for the membrane transport of a large number of endogenous and xenobiotic …