Autophagy as a novel insight into mechanism of Danqi pill against post-acute myocardial infarction heart failure

X Wang, Y Jiang, Q Zhang, X Tian, Q Sun… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Danqi Pill, composed of the root of Salvia
miltiorrhiza Bunge and the root of Panax notoginseng, is effective in the clinical treatment of …

Sophoricoside ameliorates cardiac hypertrophy by activating AMPK/mTORC1-mediated autophagy

M Gao, F Hu, M Hu, Y Hu, H Shi, GJ Zhao… - Bioscience …, 2020 - portlandpress.com
Aim: The study aims to evaluate protective effects of sophoricoside (Sop) on cardiac
hypertrophy. Meanwhile, the potential and significance of Sop should be broadened and it …

Corosolic acid ameliorates cardiac hypertrophy via regulating autophagy

ZP Wang, D Shen, Y Che, YG Jin, SS Wang… - Bioscience …, 2019 - portlandpress.com
Aim: In this work, we explored the role of corosolic acid (CRA) during pressure overload-
induced cardiac hypertrophy. Methods and results: Cardiac hypertrophy was induced in …

Inhibition of autophagy prevents Panax notoginseng saponins (PNS) protection on cardiac myocytes against endoplasmic reticulum (ER) stress-induced mitochondrial …

J Chen, L Li, X Bai, L Xiao, J Shangguan… - Frontiers in …, 2021 - frontiersin.org
Endoplasmic reticulum (ER) stress is often closely linked to autophagy, hypoxia signaling,
mitochondrial biogenesis and reactive oxygen species (ROS) responses. Understanding the …

Curcumin Alleviates D‐Galactose‐Induced Cardiomyocyte Senescence by Promoting Autophagy via the SIRT1/AMPK/mTOR Pathway

L Yang, J Shi, X Wang, R Zhang - … ‐Based Complementary and …, 2022 - Wiley Online Library
Oxidative stress and impaired autophagy are the hallmarks of cardiac aging. However, there
are no specific drugs available to prevent cardiac aging. Curcumin is a natural polyphenolic …

[HTML][HTML] Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K‑AKT‑mTOR pathway in osteoarthritic chondrocytes …

Y Zhang, W Cai, G Han, S Zhou… - International …, 2020 - spandidos-publications.com
Panax notoginseng saponins (PNS) are active extracts obtained from the P. notoginseng
plant. PNS exhibit various anti‑inflammatory, anti‑oxidant and anti‑aging pharmacological …

Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats

H He, J Xu, Y Xu, C Zhang, H Wang, Y He… - Journal of …, 2012 - Elsevier
AIM: To study the cardioprotective effects of saponins from Panax japonicus (SPJ) on acute
myocardial ischemia injury rats induced by ligating of the left anterior descending branch …

[HTML][HTML] Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and …

Y Gao, D Yuan, L Gai, X Wu, Y Shi, Y He, C Liu… - Journal of ginseng …, 2021 - Elsevier
Background The decreased renal function is known to be associated with biological aging,
of which the main pathological features are chronic inflammation and renal interstitial …

Panax notoginseng saponins inhibit ischemia-induced apoptosis by activating PI3K/Akt pathway in cardiomyocytes

S Chen, J Liu, X Liu, Y Fu, M Zhang, Q Lin, J Zhu… - Journal of …, 2011 - Elsevier
AIM OF THIS STUDY: The panax notoginseng saponins (PNS) have been clinically used for
the treatment of cardiovascular diseases and stroke in China. Evidences demonstrated that …

Yangxinkang tablet protects against cardiac dysfunction and remodelling after myocardial infarction in rats through inhibition of AMPK/mTOR-mediated autophagy

P Ren, Z Zhang, P Wang, H Zhu, Z Li - Pharmaceutical biology, 2020 - Taylor & Francis
Context Acute myocardial infarction (AMI) is defined as myocardial necrosis. Clinicians use
the traditional Chinese patent medicine Yangxinkang Tablet (YXK) to treat chronic heart …