Anemarrhena asphodeloides Bunge total saponins ameliorate diabetic cardiomyopathy by modifying the PI3K/AKT/HIF-1α pathway to restore glycolytic metabolism

L Zhong, J Li, J Yu, X Cao, J Du, L Liang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Based on the theory of traditional Chinese medicine
(TCM), diabetic cardiomyopathy (DCM) belongs to the category of" Xiaoke disease" …

Global gene expression analysis using RNA-seq reveals the new roles of Panax notoginseng saponins in ischemic cardiomyocytes

S Chen, Y Wu, X Qin, P Wen, J Liu, M Yang - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Panax notoginseng saponins (PNS), the main active
ingredients of Panax notoginseng (Burkill) FH Chen, have been clinically used for …

[HTML][HTML] Cardiac senescence is alleviated by the natural flavone acacetin via enhancing mitophagy

YX Hong, WY Wu, F Song, C Wu, GR Li… - Aging (Albany NY …, 2021 - ncbi.nlm.nih.gov
Cardiac senescence is associated with cardiomyopathy which is a degenerative disease in
the aging process of the elderly. The present study investigates using multiple experimental …

Oral treatment with herbal formula B307 alleviates cardiac failure in aging R6/2 mice with Huntington's disease via suppressing oxidative stress, inflammation, and …

CL Lin, SE Wang, CH Hsu, SJ Sheu… - Clinical Interventions in …, 2015 - Taylor & Francis
Cardiac failure is often observed in aging patients with Huntington's disease (HD). However,
conventional pharmacological treatments for cardiac failure in HD patients have rarely been …

Autophagy maintains cardiac function in the starved adult

G Takemura, H Kanamori, K Goto, R Maruyama… - Autophagy, 2009 - Taylor & Francis
To examine the functional significance and detailed morphological characteristics of
starvation-induced autophagy in the adult heart, we starved green fluorescent protein (GFP) …

Naoxintong/PPARγ signaling inhibits cardiac hypertrophy via activation of autophagy

S Yuan, J Jin, L Chen, Y Hou… - … and Alternative Medicine, 2017 - Wiley Online Library
As a traditional Chinese medicine, Naoxintong capsule (NXT) has been approved by China
Food and Drug Administration (CFDA), which is used for cardiocerebrovascular disease …

Qi Dan Li Xin pill improves chronic heart failure by regulating mTOR/p70S6k-mediated autophagy and inhibiting apoptosis

B Shi, Y Huang, J Ni, J Chen, J Wei, H Gao, L Li… - Scientific Reports, 2020 - nature.com
Myocardial remodeling represents a key factor in chronic heart failure (CHF) development,
and is characterized by chronic death of cardiomyocytes. Cardiac function changes may be …

Nobiletin attenuates adverse cardiac remodeling after acute myocardial infarction in rats via restoring autophagy flux

X Wu, D Zheng, Y Qin, Z Liu, G Zhang, X Zhu… - Biochemical and …, 2017 - Elsevier
Background Our previous study showed that autophagy flux was impaired with sustained
heart ischemia, which exacerbated adverse cardiac remodeling after acute myocardial …

Main active components of Si-Miao-Yong-An decoction (SMYAD) attenuate autophagy and apoptosis via the PDE5A-AKT and TLR4-NOX4 pathways in isoproterenol …

M Liao, Q Xie, Y Zhao, C Yang, C Lin, G Wang… - Pharmacological …, 2022 - Elsevier
Heart failure (HF), the main cause of death in patients with many cardiovascular diseases,
has been reported to be closely related to the complicated pathogenesis of autophagy …

Protective effect of total saponins of Panax notoginseng combined with total flavonoids of epimedium on D-galactose-incuced senescence of H9c2 cell

J Li, LL Deng, ZY Zhou, D Yuan… - Zhongguo Zhong yao …, 2017 - europepmc.org
To investigate the protective effect of Panax notoginseng saponins combined with total
flavonoids of epimedium on D-gal-induced senescence of H9c2 cells and explore its …