Abstract Ethnopharmacological relevance Optimized New Shengmai Powder (ONSMP) is a
traditional Chinese medicine (TCM) formula for heart failure treatment. MAPK signaling …

The present study was conducted to examine the role of hecogenin-3-O-β-d-glucopyranosyl
(1→ 4)-β-d-galactopyranoside (1), which is a triterpene saponin of Tribulus terrestris in …

Introduction Decreased exercise tolerance is a common symptom in patients with heart
failure, which is closely related to protein degradation and apoptosis regulated by the …

Ethnopharmacological relevance Panax notoginseng saponins (PNS) were extracted from
Panax notoginseng (Burkill) FH Chen, a natural product often used as a therapeutic agent in …

Hyperglycemia-induced reactive oxygen species (ROS) generation and Ca2+ overload
contribute to the development of diabetic cardiomyopathy. In this study, we aimed to study …

Heart failure (HF) is one of the most severe heart conditions, which lacks effective therapies.
Therefore, it is necessary to develop more efficient drugs for HF. In this study, we …

Epigallocatechin-3-gallate (EGCG) possesses anti-fibrotic potential in diverse tissues;
however, the molecular mechanisms underlying the impacts of EGCG on diabetes-induced …

Heart failure (HF) leads to an increase in morbidity and mortality globally. Tanshinone IIA is
an important traditional Chinese medicine monomer and has been shown to have …

This study aimed to explore the effects of puerarin on autophagy in cardiac hypertrophy.
Decreased 5′-adenosine monophosphate kinase (AMPK) activity alone with inhibited …

Studies have confirmed that the heart is the main target organ of lipopolysaccharide (LPS)
attacks, and 14–3-3γ and protein kinase C epsilon (PKCε) are the endogenous protective …