Background Adolescence is a period of increased vulnerability to psychiatric disorders,
including depression. Discovering novel biomarkers to identify individuals who are at high …

The Netrin-1/DCC guidance cue pathway plays a critical role in guiding growing axons
toward the prefrontal cortex during adolescence and in the maturational organization and …

Low miR-218 expression in the medial prefrontal cortex (mPFC) is a consistent trait of
depression. Here we assessed whether miR-218 in the mPFC confers resilience or …

Exposure to early life stress can interfere with neurodevelopmental trajectories to increase
the vulnerability for psychiatric disorders later in life. With this respect, epigenetic …

Understanding the epigenetic role of microRNAs (miRNAs) has been a critical development
in the field of neuropsychiatry and in understanding their underlying pathophysiology …

Emerging evidence has shown that noncoding RNAs, particularly microRNAs (miRNAs),
contribute to the pathogenesis of mood and anxiety disorders, although the molecular …

Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders
worldwide and a major public health concern that is associated with grave consequences …

Background Clinical studies suggest that heightened peripheral inflammation contributes to
the pathogenesis of stress-related disorders, including major depressive disorder. However …

Depressive disorders have complex and multi-faceted underlying mechanisms, rendering
these disorders difficult to treat consistently and effectively. One under-explored therapeutic …

Childhood environment can have a profound impact on brain structure and function.
Epigenetic mechanisms have been shown to play a critical role in adaptive and maladaptive …