Hypoxia, HIF-1α, and COVID-19: from pathogenic factors to potential therapeutic targets

ZO Serebrovska, EY Chong, TV Serebrovska… - Acta Pharmacologica …, 2020 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) and its pathogen, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the greatest current threat …

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

M Tian, W Liu, X Li, P Zhao, MA Shereen… - … and Targeted Therapy, 2021 - nature.com
Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial …

Hypoxia-inducible factor (HIF): The link between obesity and COVID-19

A AbdelMassih, E Yacoub, RJ Husseiny, A Kamel… - Obesity Medicine, 2021 - Elsevier
The COVID-19 death toll has involved to date more than 1 million confirmed deaths. The
death rate is even higher in the obese COVID-19 patients, as a result of hypoxia, due to the …

Hypoxia inducible factor-1 protects against COVID-19: A hypothesis

B Afsar, M Kanbay, RE Afsar - Medical hypotheses, 2020 - ncbi.nlm.nih.gov
The SARS-CoV-2 virus, the pathogen causing COVID 19, has been accepted as a pandemic
by the World Health Organization. The most dreadful complication COVID 19 is hypoxemia …

Hypoxia: A key feature of COVID-19 launching activation of HIF-1 and cytokine storm

M Jahani, S Dokaneheifard, K Mansouri - Journal of inflammation, 2020 - Springer
COVID-19, disease caused by the new coronavirus, SARS-CoV-2, appeared in the end of
2019 and was rapidly spread in most countries. This respiratory virus has different symptoms …

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

PAC Wing, TP Keeley, X Zhuang, JY Lee… - Cell reports, 2021 - cell.com
COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more
than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment …

HIF‐1, the Warburg Effect, and Macrophage/Microglia Polarization Potential Role in COVID‐19 Pathogenesis

E Ferraro, M Germanò, R Mollace… - Oxidative Medicine …, 2021 - Wiley Online Library
Despite the international scientific community's commitment to improve clinical knowledge
about coronavirus disease 2019 (COVID‐19), knowledge regarding molecular details …

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model

PAC Wing, M Prange-Barczynska, A Cross… - PLoS …, 2022 - journals.plos.org
Understanding the host pathways that define susceptibility to Severe-acute-respiratory-
syndrome-coronavirus-2 (SARS-CoV-2) infection and disease are essential for the design of …

Increased expression of hypoxia-induced factor 1α mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients

K Taniguchi-Ponciano, E Vadillo, H Mayani… - Annals of …, 2021 - Taylor & Francis
Background COVID-19 counts 46 million people infected and killed more than 1.2 million.
Hypoxaemia is one of the main clinical manifestations, especially in severe cases. HIF1α is …

HIF-1α is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes

T Peng, SY Du, M Son… - Proceedings of the …, 2021 - National Acad Sciences
Patients with severe COVID-19 infection exhibit a low level of oxygen in affected tissue and
blood. To understand the pathophysiology of COVID-19 infection, it is therefore necessary to …