Central precocious puberty (CPP) is the premature activation of the hypothalamus–pituitary–
gonadal axis, resulting in the early development of secondary sexual characteristics. CPP …

Objectives Recent studies have demonstrated an increase in the frequency of idiopathic
central precocious puberty (CPP) during the severe acute respiratory syndrome coronavirus …

Background Central precocious puberty (CPP) was an unexplored issue during COVID-19
pandemic and an important disease in the adolescence life. Our aim was to evaluate the …

Objective: Early puberty is development of secondary sex characteristics earlier than the
expected normal age range. We subjectively observed an increased frequency of early …

Sexual development is a complex mechanism activated by the hypothalamic-pituitary-
gonadal axis. Over the last one hundred years there has been a decline in the age at …

During the year 2020, the COVID-19 pandemic rapidly became a severe health emergency
worldwide. In order to contrast the spread of the novel SARS-CoV-2, many countries …

Neuro-biological variations in the timing of sexual maturation within a species are part of an
evolved strategy that depend on internal and external environmental conditions. An …

Home quarantine due to the global coronavirus disease 2019 (COVID‐19) pandemic has
had a significant impact on children. Lifestyle changes have led to an increase in precocious …

Background: The COVID-19 pandemic changed everyday life dramatically. Lockdowns,
imposed to prevent viral transmission have been investigated as possible contributors to …

A significant increase in precocious puberty, rapidly progressive puberty and precocious
menarche has been reported in Italy since the initial lockdown because of the pandemic …