Pregnancy requires a delicate immune balance that nurtures the allogeneic fetus, while
maintaining reactivity against pathogens. Despite increasing knowledge, data is lacking on …

During human pregnancy, trophoblast cells, the main cellular component of the placenta,
invade deeply into uterine blood vessels and the modified endometrium (decidua). Hence …

Background During early pregnancy, tolerance of the semi-allogeneic fetus necessitates
comprehensive modifications of the maternal immune system. How decidual CD8+ T (CD8+ …

STUDY QUESTION Is menstrual blood a suitable source of endometrial derived
lymphocytes? SUMMARY ANSWER Mononuclear cells isolated from menstrual samples …

Successful pregnancy requires a tightly‐regulated equilibrium of immune cell interactions at
the maternal‐fetal interface (ie, the decidual tissues), which plays a central role in the …

CD8+ T cells are the most frequent T cell population in the immune cell compartment at the
feto-maternal interface. Due to their cytotoxic potential, the presence of CD8+ T cells in the …

Aim Successful pregnancy requires balanced regulation of immune cells at the feto‐
maternal interface. Systemic monitoring of the immune system cannot precisely outline local …

The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and
develop in the uterus, despite being recognized by the maternal immune cells. Within the …

Studies of T cell-mediated immunity in the human female genital tract have been
problematic due to difficulties associated with the collection of mucosal samples …

Healthy pregnancy is the most successful form of graft tolerance, whereas preterm labor
(PTL) may represent a breakdown in maternal-fetal tolerance. Although maternal immune …