Does vascular pathology contribute to Alzheimer changes?

RN Kalaria, R Akinyemi, M Ihara - Journal of the neurological sciences, 2012 - Elsevier
In recent years there has been increased interest in whether vascular disease contributes to
Alzheimer's disease (AD). This review considers how modifiable risk factors such as …

Vascular dementia: different forms of vessel disorders contribute to the development of dementia in the elderly brain

DR Thal, LT Grinberg, J Attems - Experimental gerontology, 2012 - Elsevier
The diagnosis of vascular dementia (VaD) describes a group of various vessel disorders
with different types of vascular lesions that finally contribute to the development of dementia …

Blood–brain barrier leakage and perivascular inflammation in cerebral amyloid angiopathy

MG Kozberg, I Yi, WM Freeze, CA Auger… - Brain …, 2022 - academic.oup.com
Cerebral amyloid angiopathy is a small vessel disease associated with cortical microbleeds
and lobar intracerebral haemorrhage due to amyloid-β deposition in the walls of …

Alzheimer's disease, cerebrovascular disease, and the β-amyloid cascade

K Honjo, SE Black, NPLG Verhoeff - Canadian Journal of …, 2012 - cambridge.org
Alzheimer's disease (AD), considered the commonest neurodegenerative cause of
dementia, is associated with hallmark pathologies including extracellular amyloid-β protein …

[HTML][HTML] Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer's disease mouse model

SH Kim, JH Ahn, H Yang, P Lee, GY Koh… - Acta neuropathologica …, 2020 - Springer
Cerebral amyloid angiopathy (CAA), defined as the accumulation of amyloid-beta (Aβ) on
the vascular wall, is a major pathology of Alzheimer's disease (AD) and has been thought to …

[HTML][HTML] Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow

H Li, Q Guo, T Inoue, VA Polito, K Tabuchi… - Molecular …, 2014 - Springer
Background Accumulation and deposition of β-amyloid peptides (Aβ) in the brain is a central
event in the pathogenesis of Alzheimer's disease (AD). Besides the parenchymal pathology …

[HTML][HTML] Reconsidering the role of blood-brain barrier in Alzheimer's disease: From delivery to target

JA Sousa, C Bernardes, S Bernardo-Castro… - Frontiers in aging …, 2023 - frontiersin.org
The existence of a selective blood-brain barrier (BBB) and neurovascular coupling are two
unique central nervous system vasculature features that result in an intimate relationship …

Vascular dysfunction—the disregarded partner of Alzheimer's disease

MD Sweeney, A Montagne, AP Sagare, DA Nation… - Alzheimer's & …, 2019 - Elsevier
Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and
heterogeneous disease with multiple contributors to its pathophysiology, including vascular …

The blood‐brain barrier and cerebrovascular pathology in Alzheimer's disease

RN Kalaria - Annals of the New York Academy of Sciences, 1999 - Wiley Online Library
The pathology of Alzheimer's disease (AD) is not limited to amyloid plaques and
neurofibrillary tangles. Recent evidence suggests that more than 30% of AD cases exhibit …

β-Amyloid, blood vessels, and brain function

EE Smith, SM Greenberg - Stroke, 2009 - Am Heart Assoc
Cerebrovascular disease and Alzheimer disease are common diseases of aging and
frequently coexist in the same brain. Accumulating evidence suggests that the presence of …