The regulation of mRNA transport is a fundamental process for cytoplasmic sorting of
transcripts and spatially controlled translational derepression once properly localized. There …

Protein phosphorylation is involved at multiple steps of RNA processing and in the
regulation of protein expression. We present here the first identification of a serine/threonine …

The targeting of mRNAs to neuronal dendrites is an important protein sorting mechanism.
Recent studies have revealed that mRNAs are transported by molecular motors. The kinesin …

Subcellular localization of messenger RNA (mRNA) is a widespread phenomenon that can
impact the regulation and function of the encoded protein. In nonneuronal cells, specific …

RNA localization and local translation are important for numerous cellular functions. In
mammals, a class of mRNAs localize to cytoplasmic protrusions in an APC-dependent …

Local regulation of mRNA translation plays an important role in axon guidance, synaptic
development, and neuronal plasticity. Little is known, however, regarding the mechanisms …

RNA transport is an important and fundamental event for local protein synthesis, especially
in neurons. RNA is transported as large granules, but little is known about them. Here, we …

Synaptic structural plasticity, key to long-term memory storage, requires translation of
localized RNAs delivered by long-distance transport from the neuronal cell body …

Dendritic mRNA transport coupled with local regulation of translation enables neurons to
selectively alter the protein composition of individual postsynaptic sites. We have analyzed …

During neuronal development, local mRNA translation is required for axon guidance and
synaptogenesis, and dysregulation of this process contributes to multiple …